Effects of average reward rate on vigor as a function of individual variation in striatal dopamine.
Effects of average reward rate on vigor as a function of individual variation in striatal dopamine.
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DOI：
10.1007/s00213-021-06017-0
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发表时间：
2022-02
影响因子：
3.4
通讯作者：
Cools, Roshan
中科院分区：
文献类型：
--
作者：
Hofmans, Lieke;Westbrook, Andrew;van den Bosch, Ruben;Booij, Jan;Verkes, Robbert-Jan;Cools, Roshan
我们不仅需要不断地决定要采取哪些行动，还要决定采取何种力度。与早期的理论模型相一致，我们已经证明，我们的行动活力中的很大一部分差异可以用该行动获得的平均奖励率来解释。此外，这种激励效果的平均奖励率被证明是不同的主题内的变化多巴胺，无论是在人类个体和实验啮齿动物。在这里，我们评估了平均奖励率对活力影响的个体差异是否与健康未用药参与者纹状体多巴胺功能稳定测量的个体差异有关。44名参与者进行了一项辨别任务，以测试平均奖励率对活力指数反应时间的影响，并完成了[18 F]-DOPA PET扫描，以指数纹状体多巴胺合成能力。我们没有发现多巴胺合成能力和整个群体的平均奖励率之间的相互作用。然而，一项事后分析显示，纹状体多巴胺合成能力较高的参与者，特别是在丘脑核中，在30名最慢的参与者中，平均奖励率表现出更强的激励作用。我们的研究结果为纹状体多巴胺在平均奖励率信号传导中的作用提供了会聚证据，从而扩展了目前关于平均奖励率，活力和多巴胺之间的机械联系的文献。
We constantly need to decide not only which actions to perform, but also how vigorously to perform them. In agreement with an earlier theoretical model, it has been shown that a significant portion of the variance in our action vigor can be explained by the average rate of rewards received for that action. Moreover, this invigorating effect of average reward rate was shown to vary with within-subject changes in dopamine, both in human individuals and experimental rodents. Here, we assessed whether individual differences in the effect of average reward rate on vigor are related to individual variation in a stable measure of striatal dopamine function in healthy, unmedicated participants. Forty-four participants performed a discrimination task to test the effect of average reward rate on response times to index vigor and completed an [18F]-DOPA PET scan to index striatal dopamine synthesis capacity. We did not find an interaction between dopamine synthesis capacity and average reward rate across the entire group. However, a post-hoc analysis revealed that participants with higher striatal dopamine synthesis capacity, particularly in the nucleus accumbens, exhibited a stronger invigorating effect of average reward rate among the 30 slowest participants. Our findings provide converging evidence for a role of striatal dopamine in average reward rate signaling, thereby extending the current literature on the mechanistic link between average reward rate, vigor and dopamine.
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