Recyclable chiral diamine-polyoxometalate (POM) acids catalyzed asymmetric direct aldol reaction of aromatic aldehydes with long-chain aliphatic ketones
Recyclable chiral diamine-polyoxometalate (POM) acids catalyzed asymmetric direct aldol reaction of aromatic aldehydes with long-chain aliphatic ketones
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DOI：
10.1016/j.tetlet.2011.05.053
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发表时间：
2011-07-20
影响因子：
1.8
通讯作者：
Li, Can
中科院分区：
文献类型：
--
作者：
Gao, Qiang;Lu, Sheng-Mei;Li, Can
在这封信中，我们研究了使用手性二胺-多金属氧酸盐组合有机催化剂，长链脂肪酮与芳香醛的不对称直接羟醛反应。使用优化的催化剂在无溶剂条件下获得了高产率（高达 90%）和对映选择性（高达 90% ee）。此外，此类有机催化剂可以轻松回收并重复使用四次，而不会显着损失反应活性和对映选择性。 (C) 2011 Elsevier Ltd. 保留所有权利。
In this Letter, we studied the asymmetric direct aldol reaction of long-chain aliphatic ketones with aromatic aldehydes, using chiral diamine-polyoxometalate acid combined organocatalysts. High yields (up to 90%) and enantioselectivities (up to 90% ee) were obtained under solvent-free conditions with the optimized catalyst. Furthermore, such organocatalysts could be easily recycled and reused for four times without significant loss of reactivity and enantioselectivity. (C) 2011 Elsevier Ltd. All rights reserved.