Assessing drinking outcomes in alcohol treatment efficacy studies: Selecting a yardstick of success
Assessing drinking outcomes in alcohol treatment efficacy studies: Selecting a yardstick of success
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DOI：
10.1097/01.alc.0000091227.26627.75
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发表时间：
2003-10-01
影响因子：
3.2
通讯作者：
Agrawal, S
中科院分区：
文献类型：
--
作者：
Sobell, LC;Sobell, MB;Agrawal, S
背景：尽管酒精治疗功效试验的数量不断增加，但对于如何最好地衡量结果尚未达成共识。为了推进在临床疗效研究中测量结果时建立跨试验一致性的目标，国家酒精滥用和酒精中毒研究所召集了一个专家小组，并责成他们进行探索、辩论，并最终选择用于未来酒精治疗研究的“哨兵”或“最佳”结果测量。本文是在国家酒精滥用和酒精中毒研究所会议上发表的一系列文章中的一篇，其目的是讨论 (1) 选择最佳结果测量的基本原理，(2) 最佳结果测量的必要特征，(3) 选择最佳测量的效用，以及 (4) 哪些饮酒评估方法可用于收集数据来描绘最佳结果测量。方法：至少，“最佳”测量的标准包括它在心理测量上是合理的。此外，它应该在该领域拥有相当大的流通量，从而增加其采用的前景。该措施还应符合该领域最感兴趣和相关的概念（例如，直接反映酒精治疗的基本目标）。鉴于这些非常理想的特征，会议选择了重度饮酒天数百分比作为酒精治疗结果的实用且相关的衡量标准。结论：重度饮酒天数百分比应该是酒精治疗结果的最佳衡量标准。目前，每日饮酒估计方法对于收集能够反映最佳措施的数据最有用。此外，通过日常饮酒估计方法收集的数据可用于研究临床研究人员感兴趣的各种其他结果变量。
Background: Although the number of alcohol treatment efficacy trials has mushroomed, there is no consensus on how best to measure outcomes. To advance the goal of establishing cross-trial consistency in measuring outcomes in clinical efficacy studies, the National Institute on Alcohol Abuse and Alcoholism convened a panel of experts and charged them with exploring, debating, and, ultimately, selecting a "sentinel" or "optimal" outcome measure to be used in future alcohol treatment studies. The goal of this article, one in a series of several presented at the National Institute on Alcohol Abuse and Alcoholism conference, is to discuss (1) the rationale underlying selection of an optimal outcome measure, (2) the necessary characteristics of an optimal outcome measure, (3) the utility of selecting an optimal measure, and (4) which drinking assessment methods could be used to collect data to portray the optimal outcome measure.Methods: At a minimum, the criteria for an "optimal" measure include that it be psychometrically sound. In addition, it should have considerable currency in the field, thereby increasing its prospects for adoption. The measure should also be consistent with the concepts of greatest interest and relevance to the field (e.g., directly reflect the fundamental goal of alcohol treatment). In light of these highly desired features, percent of days heavy drinking was chosen at the conference as a practical and relevant measure of alcohol treatment outcome.Conclusions: Percent of days heavy drinking should be the optimal measure of alcohol treatment outcome. Currently, daily drinking estimation methods are the most useful for gathering data that can reflect the optimal measure. In addition, data gathered by daily drinking estimation methods can be used to study a variety of other outcome variables of interest to clinical researchers.