Surface acoustic waves in biosensing applications
Surface acoustic waves in biosensing applications
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DOI：
10.1016/j.snr.2021.100041
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发表时间：
2021-04-27
影响因子：
5.9
通讯作者：
Bhethanabotla, Venkat R.
中科院分区：
文献类型：
--
作者：
Huang, Yuqi;Das, Pradipta Kr;Bhethanabotla, Venkat R.
本文综述了声表面波在生物传感中的应用。首先提供关于液体介质中的声波传播的理论方面和建模原理的简要背景。随后，不同类型的表面声波（SAW）产生的压电基板上进行了讨论，与波的形成，工作原理和材料的考虑的基础。SAW生物传感器的设计，已开发，以实现增强的传感器功能的几个进步也提出。本文综述了声表面波器件在不同生物传感应用中的不同传感能力，如细胞的检测和操作，蛋白质、气体分子和DNA杂交的定量。生物污损的挑战，这可能会影响生物测定的灵敏度和特异性，详细说明。几种用于减少生物污损的技术进行了讨论，包括一个基于声流使用瑞利SAW。由于其能够减轻由于生物污垢引起的传感器信号干扰，并使用声流减少孵育时间，并且结合其高灵敏度，SAW可以用作各种基于需求点（PON）的生物传感应用的成本效益平台。
In this paper, we review the utilization of surface acoustic waves in biosensing applications. A brief background on the theoretical aspects and on the modeling principles for acoustic wave propagation in a liquid medium is provided first. Subsequently, different types of surface acoustic waves (SAWs) generated on piezoelectric substrates are discussed, with the basics of wave formation, operation principles, and material considerations. Several advancements in SAW biosensor design that have been developed to achieve enhanced sensor functionality are also presented. We have overviewed different sensing capabilities of SAW devices in different biosensing applications, such as the detection and manipulation of cells, and the quantification on proteins, vapor molecules and DNA hybridizations. The challenge of biofouling, which can affect the sensitivity and specificity of bioassays, is addressed in detail. Several techniques used to reduce biofouling are discussed including one based on acoustic streaming using Rayleigh SAWs. With their ability to mitigate sensor signal interference due to biofouling, and reduce incubation times using acoustic streaming, and combined with their high sensitivity, SAWs can be used as cost-effective platforms for various point of need (PON) based biosensing applications.