Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration
Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration
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DOI：
10.1016/s0166-4328(02)00045-1
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发表时间：
2002-08-21
影响因子：
2.7
通讯作者：
Rudy, JW
中科院分区：
文献类型：
--
作者：
Barrientos, RM;O'Reilly, RC;Rudy, JW
预先暴露于环境中有助于产生少量的环境恐惧条件反射，这种恐惧条件反射通常是由立即休克产生的。这种情境预暴露易化效应为研究大鼠的情境学习提供了一种方便的方法。我们最近报道，顺行性损伤背海马阻止这种促进。本实验加强了这一结论表明，蛋白质合成抑制剂，茴香霉素，注射到背侧海马体后，上下文预曝光也显着降低了促进作用。然而，在立即休克后立即给予同样的治疗对易化没有影响。这些结果支持了以下假设：（a）情境恐惧涉及两个过程，即获取和存储情境的连接表征并将该表征与恐惧相关联;（B）海马通过参与情境记忆表征的存储而促成情境恐惧。(C)2002 Elsevier Science B. V.保留所有权利。
Pre-exposure to the context facilitates the small amount of contextual fear conditioning that is normally produced by immediate shock. This context pre-exposure facilitation effect provides a convenient way to study the rat's learning about context. We recently reported that anterograde damage to dorsal hippocampus prevents this facilitation. The present experiments strengthen this conclusion by showing that the protein synthesis inhibitor, anisomycin, injected bilaterally into the dorsal hippocampus following context pre-exposure also significantly reduces the facilitation effect. The same treatment given immediately after immediate shock, however, had no effect on facilitation. These results support theories that assume that, (a) contextual fear involves two processes, acquiring and storing a conjunctive representation of a context and associating that representation with fears and (b) the hippocampus contributes to contextual fear by participating in the storag of the memory representation of the context. (C) 2002 Elsevier Science B.V. All rights reserved.