Synthesis of peptides by the solid-phase method. 6. Neurotensin, fragments, and analogues.
Synthesis of peptides by the solid-phase method. 6. Neurotensin, fragments, and analogues.
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固相法合成肽。
DOI：
10.1021/jm00136a004
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发表时间：
1981
影响因子：
7.3
通讯作者：
F. Rioux
中科院分区：
文献类型：
--
作者：
S. St.;J. Lalonde;M. Gendreau;R. Quirion;D. Regoli;F. Rioux
神经降压素 (NT) 和 24 种相关化合物，包括母体分子 C 末端修饰的片段或类似物，已通过固相方法制备。经阳离子交换色谱纯化后，通过薄层色谱、氨基酸分析、元素分析和高压液相色谱对化合物进行表征。在大鼠胃条、豚鼠离体自发搏动心房和灌注大鼠心脏冠状动脉中评估了肽的刺激作用。讨论了这些化合物的生物活性之间的差异。
Neurotensin (NT) and 24 related compounds, including fragments or analogues modified at the C-terminal end of the parent molecule, have been prepared by the solid-phase method. After purification by cation-exchange chromatography, the compounds were characterized by thin-layer chromatography, amino acid analysis, elemental analysis, and high-pressure liquid chromatography. The stimulating effects of the peptides were evaluated in rat stomach strips, in isolated spontaneously beating atria of guinea pigs, and in the coronaries of perfused rat hearts. The differences between the biological activities of these compounds are discussed.