Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells.
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells.
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DOI：
10.1101/gad.349276.121
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发表时间：
2022-02-01
影响因子：
10.5
通讯作者：
Mohr I
中科院分区：
文献类型：
--
作者：
Burgess HM;Vink EI;Mohr I
在这篇综述中，Burgess等人。讨论在动物感染病毒的细胞中控制信使核糖核酸衰变、修饰和翻译的策略和机制。除了解决感染后果，病毒感染细胞中的转录后基因调控是健康和疾病中基本的生理应激反应的缩影。由于它们对宿主核糖体翻译mRNA的分类要求，病毒提供了丰富的遗传模型来研究感染触发的生物应激如何在转录后重塑基因表达。通过增选和颠覆控制mRNA衰退、修饰和翻译的细胞途径，转录后过程的全球格局迅速被病毒编码因子重塑。同时的宿主细胞内在对策同样征召转录后策略来动员关键的先天免疫防御。在这里，我们回顾了在动物病毒感染的细胞中控制信使核糖核酸衰退、修饰和翻译的策略和机制。除了解决感染后果，病毒感染细胞中的转录后基因调控是健康和疾病中基本的生理应激反应的缩影。
In this review, Burgess et al. discuss strategies and mechanisms that control mRNA decay, modification, and translation in animal virus-infected cells. Besides settling infection outcomes, post-transcriptional gene regulation in virus-infected cells epitomizes fundamental physiological stress responses in health and disease. With their categorical requirement for host ribosomes to translate mRNA, viruses provide a wealth of genetically tractable models to investigate how gene expression is remodeled post-transcriptionally by infection-triggered biological stress. By co-opting and subverting cellular pathways that control mRNA decay, modification, and translation, the global landscape of post-transcriptional processes is swiftly reshaped by virus-encoded factors. Concurrent host cell-intrinsic countermeasures likewise conscript post-transcriptional strategies to mobilize critical innate immune defenses. Here we review strategies and mechanisms that control mRNA decay, modification, and translation in animal virus-infected cells. Besides settling infection outcomes, post-transcriptional gene regulation in virus-infected cells epitomizes fundamental physiological stress responses in health and disease.
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