Kupffer cells in the liver.
Kupffer cells in the liver.
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DOI：
10.1002/cphy.c120026
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发表时间：
2013-04
影响因子：
5.8
通讯作者：
Nagy LE
中科院分区：
文献类型：
--
作者：
Dixon LJ;Barnes M;Tang H;Pritchard MT;Nagy LE
枯否细胞是单核吞噬细胞系统的重要组成部分，是肝脏和全身对病原体反应的中心。枯否细胞正在重新成为肝损伤和修复的关键介质。枯否细胞表现出巨大的可塑性;取决于局部代谢和免疫环境，然后可以表达一系列极化表型，从促炎M1表型到替代/M2表型。可以区分多种M2表型，每种表型都参与炎症和伤口愈合的消退。在这里，我们提供了最近研究的最新进展，这些研究有助于描述枯否细胞对不同类型肝损伤的贡献，重点是酒精性和非酒精性肝病。我们对枯否细胞功能和调节的理解的这些最新进展可能会为枯否细胞的治疗操作提供新的见解，以促进炎症的解决并增强肝脏疾病的伤口愈合。
Kupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as critical mediators of both liver injury and repair. Kupffer cells exhibit a tremendous plasticity; depending on the local metabolic and immune environment, then can express a range of polarized phenotypes, from the proinflammatory M1 phenotype to the alternative/M2 phenotype. Multiple M2 phenotypes can be distinguished, each involved in the resolution of inflammation and wound healing. Here, we have provided an update on recent research that has contributed to the developing delineation of the contribution of Kupffer cells to different types of liver injury, with an emphasis on alcoholic and nonalcoholic liver diseases. These recent advances in our understanding of Kupffer cell function and regulation will likely provide new insights into the potential for therapeutic manipulation of Kupffer cells to promote the resolution of inflammation and enhance wound healing in liver disease.