Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities
Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities
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DOI：
10.1176/appi.ajp.162.2.361
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发表时间：
2005-02-01
影响因子：
17.7
通讯作者：
Grob, CS
中科院分区：
文献类型：
--
作者：
Chang, L;Ernst, T;Grob, CS
目的：质子磁共振波谱(H-1-MRS)显示慢性甲基苯丙胺吸毒者和HIV感染者神经元标志物N-乙酰天冬氨酸降低，神经胶质标志物肌醇升高。方法：对68例HIV阳性受试者进行H-1-MRS检查，其中24例长期使用甲基苯丙胺，平均终生暴露2,167 g[SD=2,788]，最后一次使用甲基苯丙胺平均4.9个月[SD=6.0]；44名无药物滥用史)和75名艾滋病毒阴性受试者(36名有长期甲基安非他明吸毒史，平均终生接触8,241克[SD=16,850]，最近一次使用平均6.3个月[SD=7.8]；39名无吸毒史)。结果：有慢性甲基苯丙胺吸毒史的HIV阴性受试者额叶白质和基底节神经元标志物N-乙酰天冬氨酸的浓度低于无吸毒史的受试者，而胆碱化合物和神经胶质标志物肌醇的浓度高于无吸毒史的受试者。与HIV阴性状态相比，HIV阳性状态与额叶皮质中N-乙酰天冬氨酸和肌酸浓度较低以及白质中肌醇浓度较高有关。与无吸毒史的HIV阴性受试者相比，HIV感染者和长期使用甲基苯丙胺的受试者的代谢产物平均浓度对三个区域的N-乙酰天冬氨酸(基底节-9%，额叶白质-7%，额灰质-6%)、基底节肌酸(-7%)和额叶白质肌醇(+11%)具有相加作用。结论：HIV和慢性甲基苯丙胺的联合作用符合相加模型，提示同时存在额外的神经元损伤和胶质细胞激活。
Objective: Proton magnetic resonance spectroscopy (H-1-MRS) showed decreased neuronal marker N- acetylaspartate and increased glial marker myo-inositol in subjects with chronic methamphetamine use and in subjects infected with HIV. The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities.Method: H-1-MRS was performed in 68 HIV-positive subjects ( 24 with a history of chronic methamphetamine use with a lifetime exposure of a mean of 2,167 g [ SD= 2,788] and last use a mean of 4.9 months earlier [ SD= 6.0]; 44 with no history of drug abuse) and 75 HIV-negative subjects ( 36 with a history of chronic methamphetamine use with a lifetime exposure of a mean of 8,241 g [ SD= 16,850] and last use a mean of 6.3 months earlier [ SD= 7.8]; 39 with no history of drug abuse). Concentrations of N- acetylaspartate, creatine, choline, and myo-inositol were measured in the frontal cortex, frontal white matter, and basal ganglia.Results: HIV- negative subjects with a history of chronic methamphetamine use showed lower concentrations of the neuronal marker N-acetylaspartate in the frontal white matter and basal ganglia and higher concentrations of choline compounds and the glial marker myo-inositol in the frontal cortex, relative to subjects with no history of drug abuse. HIV-positive status was associated with lower concentrations of N-acetylaspartate and creatine in the frontal cortex and higher concentrations of myo-inositol in the white matter, compared with HIV-negative status. Compared to the mean concentrations of metabolites in HIV-negative subjects with no history of drug abuse, the mean concentrations in subjects with HIV and chronic methamphetamine use showed additive effects on N-acetylaspartate in all three regions ( - 9% in the basal ganglia, - 7% in the frontal white matter, and - 6% in the frontal gray matter), on creatine in the basal ganglia ( - 7%), and on myo-inositol in the frontal white matter (+11%).Conclusions: The combined effects of HIV and chronic methamphetamine use were consistent with an additive model, suggesting additional neuronal injury and glial activation due to the comorbid conditions.