Tribbles: 'puzzling' regulators of cell signalling
Tribbles: 'puzzling' regulators of cell signalling
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DOI：
10.1042/bst0390684
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发表时间：
2011-04-01
影响因子：
3.9
通讯作者：
Kiss-Toth, Endre
中科院分区：
文献类型：
--
作者：
Kiss-Toth, Endre
感知和解释细胞外信号以响应环境的变化，从进化的一开始就是所有生命形式的基本特征。为了实现这一功能，蛋白质网络已经进化，形成细胞内信号转导机制。尽管这些信号转导系统的适当控制对于体内平衡是必不可少的，但是信号转导的失调导致疾病并且通常导致生物体的死亡。tribbles家族的假激酶近年来已经出现作为信号转导的关键控制器，通过它们与几个关键激酶，泛素连接酶和转录因子的相互作用。根据它们在调节重要信号通路中的作用，tribbles家族的成员与一系列人类疾病的发展有关。而我们的机制，这些蛋白质如何有助于疾病的理解是远远不够的，本文件试图总结一些最重要的最新进展，在这一领域的研究。
Sensing and interpreting extracellular signals in response to changes in the environment has been a fundamental feature of all life forms from the very beginning of evolution. To fulfil this function, networks of proteins have evolved, forming the intracellular signal transduction machinery. Whereas the appropriate control of these signal transduction systems is essential to homoeostasis, dysregulation of signalling leads to disease and often the death of the organism. The tribbles family of pseudokinases have emerged in recent years as key controllers of signal transduction via their interactions with several key kinases, ubiquitin ligases and transcription factors. In line with their role in regulating fundamentally important signalling pathways, members of the tribbles family have been implicated in the development of a range of human diseases. Whereas our mechanistic understanding of how these proteins contribute to disease is far from complete, the present paper attempts to summarize some of the most important recent developments in this field of research.