EPR oximetry in three spatial dimensions using sparse spin distribution
EPR oximetry in three spatial dimensions using sparse spin distribution
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DOI：
10.1016/j.jmr.2008.05.004
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发表时间：
2008-08-01
影响因子：
2.2
通讯作者：
Kuppusamy, Periannan
中科院分区：
文献类型：
--
作者：
Som, Subhojit;Potter, Lee C.;Kuppusamy, Periannan
提出了一种利用连续波电子顺磁共振成像技术快速测量三维空间氧分压的方法。采用微粒顺磁探针来在感兴趣体积中产生自旋的稀疏分布。通过改变所施加的磁梯度Held的空间取向和强度来收集编码位置和谱线宽度的信息。数据处理利用自旋的空间稀疏性来检测具有非零自旋的体素并估计这些体素的谱线宽。与使用传统光谱空间成像的四维层析重建相比，自旋位置和线宽的简约表示允许数据采集时间减少一个数量级。建议的血氧测定方法的实验证明，八正丁氧基萘（LiNc-BuO）探头使用L-波段EPR光谱仪。(c)2008年爱思唯尔公司All rights reserved.
A method is presented to use continuous wave electron paramagnetic resonance imaging for rapid measurement of oxygen partial pressure in three spatial dimensions. A particulate paramagnetic probe is employed to create a sparse distribution of spins in a volume of interest. Information encoding location and spectral linewidth is collected by varying the spatial orientation and strength of an applied magnetic gradient Held. Data processing exploits the spatial sparseness of spins to detect voxels with non-zero spin and to estimate the spectral linewidth for those voxels. The parsimonious representation of spin locations and linewidths permits an order of magnitude reduction in data acquisition time, compared to four-dimensional tomographic reconstruction using traditional spectral-spatial imaging. The proposed oximetry method is experimentally demonstrated for a lithium octa-n-butoxy naphthalocyanine (LiNc-BuO) probe using an L-band EPR spectrometer. (c) 2008 Elsevier Inc. All rights reserved.