The functional significance of symptomatology and cognitive function in schizophrenia
The functional significance of symptomatology and cognitive function in schizophrenia
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DOI：
10.1016/s0920-9964(97)00010-8
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发表时间：
1997-05-03
影响因子：
4.5
通讯作者：
Miller, AL
中科院分区：
文献类型：
--
作者：
Velligan, DI;Mahurin, RK;Miller, AL
两项研究检查了精神分裂症患者的阳性和阴性症状、认知功能和进行基本日常生活活动的能力之间的关系。在研究 1 中，使用简明精神病评定量表（阳性症状）、阴性症状评估（阴性症状和认知功能）和功能需求评估（日常生活活动）对 112 名用药患者进行了评估。研究 2（n = 41）采用了相同的症状学测量方法，并添加了全面的神经心理学测试组合。两项研究的回归分析都确定，症状学预测的基本日常生活活动能力的差异相对较小。认知功能，无论是使用阴性症状评估的认知子量表还是综合神经心理学测试组进行评估，都可以预测功能需求评估分数中超过 40% 的差异。认知预测同时发生的症状和日常生活活动以及症状对日常生活活动几乎没有直接影响的路径模型符合数据。讨论了心理社会干预计划中解决认知缺陷的重要性。
The relationships between positive and negative symptomatology, cognitive function, and the ability to perform basic activities of daily living in patients with schizophrenia were examined in two studies. In study 1, 112 medicated patients were assessed utilizing the Brief Psychiatric Rating Scale (positive symptoms), the Negative Symptom Assessment (negative symptoms and cognitive function), and the Functional Needs Assessment (activities of daily living). Study 2 (n = 41), utilized the same measures of symptomatology and added a comprehensive neuropsychological test battery. Regression analyses in both studies determined that symptomatology predicts a relatively small amount of the variance in the ability to perform basic activities of daily living. Cognitive function, whether assessed with the Cognition subscale of the Negative Symptom Assessment or a comprehensive neuropsychological test battery, predicted over 40% of the variance in scores on the Functional Needs Assessment. A path model in which cognition predicted both concurrent symptomatology and activities of daily living and where symptomatology had little direct impact upon activities of daily living fit the data. The importance of addressing cognitive deficits in psychosocial intervention programs is discussed.