Drug releasing behavior of hybrid micelles containing polypeptide triblock copolymer
Drug releasing behavior of hybrid micelles containing polypeptide triblock copolymer
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含多肽三嵌段共聚物杂化胶束的药物释放行为
DOI：
10.1016/j.biomaterials.2008.09.010
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发表时间：
2009-01-01
期刊：
影响因子：
14
通讯作者：
Wang, Xiao-Song
中科院分区：
文献类型：
--
作者：
Lin, Jiaping;Zhu, Jianqi;Wang, Xiao-Song
We report a new type of hybrid polymeric micelles for drug delivery applications. These micelles consist of PLGA (PLGA: poly(L-glutamic acid)) and PEG (PEG: polyethylene glycol) mixed corona chains. In acidic condition, PLGA undergoes a transformation from water-soluble random coils to water-insoluble a-helix, leading to microphase separation in micelle coronas and formation of PEG channels. These channels connect the inner core and the outer milieu, accelerating the diffusion of drugs from micelles. The micelles were prepared through a co-micellization of PLGA-b-PPO-b-PLGA (PPO: poly(propylene oxide)) and PEG-b-PPO in water. During the self-assembly, the PPO blocks of both block copolymers aggregated into cores that were surrounded by mixed corona chains of PLGA and PEG blocks. We confirmed this structure by using a number of characterization techniques including nuclear magnetic resonance spectroscopy, zeta potential, circular dichroism, and dynamic light scattering. We also performed molecular dynamics (MD) simulations to verify the models of the hybrid micelle structure. One advantage of the hybrid micelles as drug carriers is their tunable release rate without sacrificing colloidal stability. The rate can be tuned by either micelle structures such as the composition of the mixture or external parameters such as pH. (C) 2008 Elsevier Ltd. All rights reserved.
