Evaluation of progesterone synthesis in rabbit placentas.
Evaluation of progesterone synthesis in rabbit placentas.
复制标题
兔胎盘中黄体酮合成的评价。
作者：
R. Thau;J. Lanman
通过切除21天妊娠雌兔的卵巢并通过Depo-Provera®处理维持妊娠3天来研究兔胎盘对母体血浆孕酮的贡献。卵巢切除术后，母体血浆孕酮水平在24小时内下降到非妊娠值，并保持较低水平，表明胎盘对血浆孕酮没有可检测的影响。无论是否接受Depo-Provera®治疗，假卵巢切除的兔与未手术、未治疗的对照相比，孕酮浓度没有显著差异，表明Depo-Provera对非卵巢切除的妊娠雌兔中孕酮产生缺乏反馈控制。（内分泌学94：925，1974）
The contribution of the rabbit placenta to maternal plasma progesterone was investigated by ovariectomizing 21-day pregnant does and maintaining pregnancy for 3 days by Depo-Provera® treatment. Following ovariectomy, maternal plasma progesterone levels decreased to nonpregnant values within 24 hr and remained low, indicating that the placentas do not contribute a detectable amount to plasma progesterone. Sham ovariectomized rabbits, whether on Depo-Provera® treatment or not, showed no significant difference in progesterone concentrations in comparison to unoperated, untreated controls, suggesting the lack of a feedback control exerted by Depo-Provera over progesterone production in nonovariectomized pregnant does. (Endocrinology 94: 925, 1974)