Transcriptional regulation of mouse hypoglossal motor neuron somatotopic map formation
Transcriptional regulation of mouse hypoglossal motor neuron somatotopic map formation
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小鼠舌下运动神经元体位图形成的转录调控
DOI：
10.1007/s00429-015-1160-2
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发表时间：
2016-11
影响因子：
3.1
通讯作者：
Stifani Stefano
中科院分区：
文献类型：
--
作者：
Chen Xin;Wang Jae Woong;Salin-Cantegrel Adele;Dali Rola;Stifani Stefano
降压核中的体细胞神经元支配舌头肌肉控制着重要功能，例如咀嚼，吞咽和呼吸。功能性降低神经回路的形成取决于建立精确的降压运动
Somatic motor neurons in the hypoglossal nucleus innervate tongue muscles controlling vital functions such as chewing, swallowing and respiration. Formation of functional hypoglossal nerve circuits depends on the establishment of precise hypoglossal motor neuron maps correlating with specific tongue muscle innervations. Little is known about the molecular mechanisms controlling mammalian hypoglossal motor neuron topographic map formation. Here we show that combinatorial expression of transcription factors Runx1, SCIP and FoxP1 defines separate mouse hypoglossal motor neuron groups with different topological, neurotransmitter and calcium-buffering phenotypes. Runx1 and SCIP are coexpressed in ventromedial hypoglossal motor neurons involved in control of tongue protrusion whereas FoxP1 is expressed in dorsomedial motor neurons associated with tongue retraction. Establishment of separate hypoglossal motor neuron maps depends in part on Runx1-mediated suppression of ventrolateral and dorsomedial motor neuron phenotypes and regulation of FoxP1 expression pattern. These findings suggest that combinatorial actions of Runx1, SCIP and FoxP1 are important for mouse hypoglossal nucleus somatotopic map formation.
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影响因子：
9.8
作者：
Palmesino E;Rousso DL;Kao TJ;Klar A;Laufer E;Uemura O;Okamoto H;Novitch BG;Kania A
通讯作者：
Kania A
DOI：
10.1242/dev.097188
发表时间：
2014-02
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Machado CB;Kanning KC;Kreis P;Stevenson D;Crossley M;Nowak M;Iacovino M;Kyba M;Chambers D;Blanc E;Lieberam I
通讯作者：
Lieberam I
影响因子：
16.2
作者：
D. Rousso;Z. Gaber;D. Wellik;E. Morrisey;B. Novitch
通讯作者：
D. Rousso;Z. Gaber;D. Wellik;E. Morrisey;B. Novitch
Foxp1/2/4 作为抑制复合物调节软骨内骨化。
影响因子：
2.7
作者：
Zhao, Haixia;Zhou, Wenrong;Yao, Zhengju;Wan, Yong;Cao, Jingjing;Zhang, Lingling;Zhao, Jianzhi;Li, Hanjun;Zhou, Rujiang;Li, Baojie;Wei, Gang;Zhang, Zhenlin;French, Catherine A.;Dekker, Joseph D.;Yang, Yingzi;Fisher, Simon E.;Tucker, Haley O.;Guo, Xizhi
通讯作者：
Guo, Xizhi
影响因子：
64.5
作者：
Dasen, Jeremy S.;De Camilli, Alessandro;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.