Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes.
Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes.
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roux-en-y胃旁路对具有正常葡萄糖耐受性和2型糖尿病肥胖受试者的肥胖受试者的禁食和餐后炎症参数的影响。
DOI：
10.1186/s13098-015-0012-9
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发表时间：
2015
影响因子：
4.8
通讯作者：
Madsbad S
中科院分区：
文献类型：
--
作者：
Lindegaard KK;Jorgensen NB;Just R;Heegaard PM;Madsbad S
肥胖的特征是低度炎症和脂肪组织炎性细胞因子的分泌改变。减肥已被证明可以减少炎症；然而，大规模减肥期间细胞因子谱的变化并未得到很好的描述。本研究探讨了Roux-en-Y胃旁路手术(RYGB)在肥胖2型糖尿病(T2D)患者和肥胖正常糖耐量(NGT)患者中降低促炎细胞因子循环水平，同时增加抗炎细胞因子的假说。分别于手术前、术后1周、3个月、1年对13例T2D肥胖者[体重12 9 ± 14 mg，糖化血红蛋白(HbA1c)；7 ± 0.9%，体重指数(BMI)；43.2 ± 5.3 kg/m2，平均 ± SD]和12例匹配肥胖者[体重(12 7 ± 15 kg，HbA1c；5.5 ± 0.4%，BMI；41.5 ± 4.8 kg/m2，平均 ± SD])进行了术前、术后1周、术后3个月、1年的检查。测定空腹和流食期间血清IL-6、瘦素、脂联素、IL-8、转化生长因子-β(TGFR-β)、胰岛素样生长素样多肽-1(GLP-1)的水平。用HOMA-IR评价胰岛素抵抗。体重减轻在两组之间没有差异。T2D患者术前HbA1c较高，HOMA-IR较低，术后一年趋于NGT患者水平。在任何时间点，两组患者的循环细胞因子浓度均无差异。术后1周循环IL-6、IL-8较术前升高，脂联素、瘦素较术前降低。术后3个月IL-8升高，瘦素降低，IL-6、转化生长因子-β、脂联素无明显变化。术后1年，IL-6、转化生长因子-β和瘦素水平较术前显著降低，而脂联素水平显著升高。RYGB治疗1年后，空腹血清IL-6和Leptin水平降低，而IL-8水平无明显变化。T2D和NGT肥胖者转化生长因子-β降低，脂联素升高。本研究首次检测了肥胖者治疗后IL-8和转化生长因子-β的水平。炎症的消退可能为减肥手术后与主要体重减轻相关的健康改善提供潜在的解释。Http://www.clinicaltrials.gov(NCT01579981)。
Obesity is characterized by low grade inflammation and an altered secretion of inflammatory cytokines from the adipose tissue. Weight loss has shown to reduce inflammation; however, changes in cytokine profiles during massive weight loss are not well described. The present study explored the hypothesis that Roux-en-Y gastric bypass (RYGB) reduces circulating levels of pro-inflammatory cytokines, while increasing anti-inflammatory cytokines in obese subjects with type 2 diabetes (T2D) and in obese normal glucose tolerant (NGT) subjects. Thirteen obese subjects with T2D [weight; 129 ± 14 kg, glycated hemoglobin (HbA1c); 7.0 ± 0.9%, body mass index (BMI); 43.2 ± 5.3 kg/m2, mean ± SD] and twelve matched obese NGT subjects [weight; 127 ± 15 kg, HbA1c; 5.5 ± 0.4%, BMI; 41.5 ± 4.8 kg/m2, mean ± SD] were examined before, one week, three months, and one year after surgery. Interleukin (IL)-6, leptin, adiponectin, IL-8, transforming growth factor beta (TGF-β), and the incretin hormone glucagon-like peptide-1 (GLP-1) were measured in the fasting state and during a liquid meal. Insulin resistance was evaluated by HOMA-IR. Weight loss did not differ between the two groups. Before surgery, HbA1c was higher and HOMA-IR lower in T2D patients, however, converged to the values of NGT subjects one year after surgery. Circulating cytokine concentrations did not differ between the two groups at any time point. One week after surgery, circulating IL-6 and IL-8 were increased, while adiponectin and leptin were reduced compared with pre-surgical concentrations. Three months after surgery, IL-8 was increased, leptin was reduced, and no change was observed for IL-6, TGF-β, and adiponectin. One year after surgery, concentrations of IL-6, TGF-β, and leptin were significantly reduced compared to before surgery, while adiponectin was significantly increased. One year after RYGB, fasting concentrations of IL-6 and leptin were reduced, while no changes were observed in IL-8. TGF-β was decreased and adiponectin increased in both T2D and NGT obese subjects. This study is the first to examine IL-8 and TGF-β in obese subject after RYGB. Resolution of inflammation could offer a potential explanation for the health improvement associated with major weight loss after bariatric surgery. http://www.clinicaltrials.gov (NCT01579981).
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影响因子：
10.9
作者：
Brown, Melissa L.;Schneyer, Alan L.
通讯作者：
Schneyer, Alan L.
影响因子：
7.7
作者：
Alessi, MC;Bastelica, D;Juhan-Vague, I
通讯作者：
Juhan-Vague, I
影响因子：
5.8
作者：
Falken, Y.;Hellstrom, P. M.;Naslund, E.
通讯作者：
Naslund, E.
DOI：
10.1152/ajpendo.00110.2003
发表时间：
2003-09-01
影响因子：
5.1
作者：
Bruun, JM;Lihn, AS;Richelsen, B
通讯作者：
Richelsen, B
DOI：
10.1016/s0006-291x(03)00090-1
发表时间：
2003-02-21
影响因子：
3.1
作者：
Fasshauer, M;Kralisch, S;Paschke, R
通讯作者：
Paschke, R