Grey-Matter Atrophy in Alzheimer's Disease is Asymmetric but not Lateralized
Grey-Matter Atrophy in Alzheimer's Disease is Asymmetric but not Lateralized
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DOI：
10.3233/jad-2011-110041
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Muehlau, Mark
中科院分区：
文献类型：
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作者：
Derflinger, Sabine;Sorg, Christian;Muehlau, Mark
在阿尔茨海默病（AD）中，脑萎缩被认为是左侧脑萎缩。在这里，我们重新研究了 35 名 AD 患者、24 名遗忘性轻度认知障碍（aMCI，一种 AD 风险增加的状态）患者和 30 名年龄匹配的健康对照 (HC) 灰质 (GM) 分布的不对称性和偏侧化（即朝向一个半球的不对称）。我们通过应用基于体素的形态测量 (VBM) 来分析 GM 分布，包括不对称性和偏侧化分析。当将 MCI 与 AD 患者进行比较时，VBM 显示内嗅、颞顶、背额、枕叶皮质以及楔前叶的 GM 损失；当将 HC 与 MCI 患者进行比较时，我们发现了类似的差异，但这种差异不太明显，尤其是在颞顶皮层和楔前叶内。对区域不对称性、区域偏侧化以及全局偏侧化的分析没有产生显着的结果。然而，从 HC 到 AD，颞叶、顶叶和枕叶的叶不对称性有所增加。此外，在 aMCI 和 AD 患者中，基于语言的神经心理学测试的表现与左半球 GM 损失的偏侧化相关。我们的结论是，原则上，AD 中的脑萎缩是不对称的而不是偏侧的。然而，在个人层面上，不对称会导致认知缺陷。
In Alzheimer's disease (AD), brain atrophy has been proposed to be left lateralized. Here, we reinvestigated the asymmetry and lateralization (i.e., asymmetry directed toward one hemisphere) of grey-matter (GM) distribution in 35 patients with AD, 24 patients with amnestic mild cognitive impairment (aMCI, a state of increased risk for AD), and 30 age-matched healthy controls (HC). We analyzed GM distribution by applying voxel-based morphometry (VBM) including analyses for asymmetry and lateralization. When comparing MCI with AD patients, VBM revealed GM loss in the entorhinal, temporoparietal, dorsofrontal, and occipital cortices as well as in the precuneus; when comparing HCs with MCI patients, we found similar differences, which were less pronounced especially within the temporoparietal cortex and precuneus. Analyses of regional asymmetry and regional lateralization as well as global lateralization did not yield significant results. However, lobar asymmetry of the temporal, parietal, and occipital lobes increased from HC to AD. Moreover, in aMCI and AD patients, performance of language-based neuropsychological tests correlated with lateralization of GM loss to the left hemisphere. We conclude that, in principle, brain atrophy in AD is asymmetric rather than lateralized. At the individual level however, asymmetry contributes to cognitive deficits.