Current situation and perspectives in drug formulation by using supercritical fluid technology
Current situation and perspectives in drug formulation by using supercritical fluid technology
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DOI：
10.1016/j.supflu.2017.12.038
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发表时间：
2018-04-01
影响因子：
3.9
通讯作者：
Crampon, Christelle
中科院分区：
文献类型：
--
作者：
Badens, Elisabeth;Masmoudi, Yasmine;Crampon, Christelle
在过去的三十年里，超临界流体（SCF）技术已应用于药品开发，使用超临界流体产生药物颗粒似乎是进行药物配制的有效方法，这些药物配制将形成符合目标规格的最终产品。本文从一个与通常不同的角度，更侧重于化学和工艺工程方面，概述了使用SCF的药物颗粒设计。简要介绍了现有工艺的主要类型，重点讨论了如何从热力学和流体力学两个方面选择合适的操作条件。结果表明，操作条件和参数可以很容易地优化，以促进进一步的工艺放大。此外，介绍了使用SCF的颗粒生成的新趋势，涉及治疗的新类型药物或过程实施方法的新方式。
Supercritical fluid (SCF) technology has been applied to drug product development over the last thirty years and drug particle generation using SCFs appears to be an efficient way to carry out drug formulation which will form end -products meeting targeted specifications. This article presents an overview of drug particle design using SCFs from a rather different perspective than usual, more focused on chemical and process engineering aspects. The main types of existing processes are described in a concise way and a focus is put on how to choose the right operating conditions considering both thermodynamic and hydrodynamic aspects. It is shown that the operating conditions and parameters can be easily optimized so as to facilitate the further process scale-up. Furthermore, the new trends in particle generation using SCFs are introduced, related either to new types of drug medicines that are treated or new ways of process implementation methods.