Astilbin Attenuates Hyperuricemia and Ameliorates Nephropathy in Fructose-Induced Hyperuricemic Rats
Astilbin Attenuates Hyperuricemia and Ameliorates Nephropathy in Fructose-Induced Hyperuricemic Rats
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DOI：
10.1055/s-0030-1271135
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发表时间：
2011-11-01
期刊：
影响因子：
2.7
通讯作者：
Li, Ping
中科院分区：
文献类型：
--
作者：
Chen, Lvyi;Lan, Zhou;Li, Ping
落新妇苷是从菝葜根茎中分离得到的一种黄酮类化合物。本研究旨在探讨落新妇苷对高尿酸血症肾病大鼠的治疗作用及其可能机制。给10%果糖诱导的高尿酸血症大鼠灌服不同剂量落新妇苷（1.25、2.5和5.0mg/kg）。结果表明，落新妇苷可显著降低血清尿酸（Sur）水平，但不抑制黄嘌呤氧化酶（XOD）活性，其作用机制为增加尿尿酸（Uur）水平和尿酸排泄分数（FEUA）。此外，肾功能参数，如血清肌酐（Scr）和血尿素氮（BUN）恢复落新妇治疗高尿酸血症大鼠。落新妇苷通过抑制转化生长因子-β 1（TGF-β 1）和结缔组织生长因子（CTGF）的表达，抑制尿酸盐（MSU）的形成，抑制前列腺素E-2（PGE（2））和白细胞介素-1（IL-1）的产生，从而发挥肾脏保护作用。这些发现为落新妇苷作为一种安全和有前途的先导化合物在开发一种疾病修饰药物，以防止高尿酸血症和肾病提供了有力的证据。
Astilbin is a flavonoid compound isolated from the rhizome of Smilax china L. The effects and possible mechanisms of astilbin on hyperuricemia and nephropathy rats were elucidated in this study. Different dosages of astilbin (1.25, 2.5, and 5.0 mg/kg) were administered to 10% fructose-induced hyperuricemic rats. The results demonstrated that astilbin significantly decreased the serum uric acid (Sur) level by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) but not inhibiting the xanthine oxidase (XOD) activity. In addition, kidney function parameters such as serum creatinine (Scr) and blood urea nitrogen (BUN) were recovered in astilbin-treated hyperuricemic rats. Further investigation indicated that astilbin prevented the renal damage against the expression of transforming growth factor-beta 1 (TGF-beta 1) and connective tissue growth factor (CTGF) and also exerted a renal protective role by inhibiting formation of monosodium urate (MSU) and production of prostaglandin E-2 (PGE(2)) and interleukin-1 (IL-1). These findings provide potent evidence for astilbin as a safe and promising lead compound in the development of a disease-modifying drug to prevent hyperuricemia and nephropathy.