TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese.
TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese.
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DOI：
10.1038/srep11900
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发表时间：
2015-07-03
影响因子：
4.6
通讯作者：
Li WD
中科院分区：
文献类型：
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作者：
Wei F;Cai C;Feng S;Lv J;Li S;Chang B;Zhang H;Shi W;Han H;Ling C;Yu P;Chen Y;Sun N;Tian J;Jiao H;Yang F;Li M;Wang Y;Zou L;Su L;Li J;Li R;Qiu H;Shi J;Liu S;Chang M;Lin J;Chen L;Li WD
为了研究2型糖尿病（T2 DM）候选基因与糖尿病微血管并发症（MVCD）之间的关联，我们在中国汉族受试者中进行了T2 DM和MVCD的病例对照关联研究。我们招募了1，939名无关的中国汉族T2 DM患者和918名血糖水平正常的非糖尿病对照者。在T2 DM患者中，1116例发生MVCD，266例有T2 DM病史>10年但从未发生MVCD。对54个候选基因中的82个单核苷酸多态性（SNPs）进行了基因分型。通过PLINK程序对T2 DM和MVCD进行离散关联研究。候选基因SNP与T2 DM之间存在显著关联，包括TOX基因的rs 1526167（等位基因A，P = 2.85 × 10−9，OR = 1.44）。CDKN 2 A/B基因的SNP rs 10811661也与2型糖尿病相关（等位基因T，P = 4.09 × 10−7，OR = 1.36）。当我们使用无MVCD的T2 DM病史>10年的对照患者时，我们发现TOX基因SNP rs 1526167的G等位基因与MVCD相关（名义P = 4.33 × 10−4）。在我们的研究中，发现TOX和CDKN 2A/B基因SNPs与2型糖尿病显著相关。TOX基因多态性可能是中国汉族人群中T2 DM发病风险较高而MVCD发病风险较低的原因。
To study associations between type 2 diabetes (T2DM) candidate genes and microvascular complications of diabetes (MVCDs), we performed case-control association studies for both T2DM and MVCDs in Han Chinese subjects. We recruited 1,939 unrelated Han Chinese T2DM patients and 918 individuals with normal blood glucose levels as nondiabetic controls. Among T2DM patients, 1116 have MVCDs, 266 have a history of T2DM of >10 years but never developed MVCDs. Eighty-two single-nucleotide polymorphisms (SNPs) in 54 candidate genes were genotyped. Discrete association studies were performed by the PLINK program for T2DM and MVCDs. Significant associations were found among candidate gene SNPs and T2DM, including rs1526167 of the TOX gene (allele A, P = 2.85 × 10−9, OR = 1.44). The SNP rs10811661 of the CDKN2A/B gene was also associated with T2DM (allele T, P = 4.09 × 10−7, OR = 1.36). When we used control patients with >10 years of T2DM history without MVCD, we found that the G allele of SNP rs1526167 of the TOX gene was associated with MVCD (nominal P = 4.33 × 10−4). In our study, significant associations were found between TOX and CDKN2A/B gene SNPs and T2DM. The TOX polymorphism might account for the higher risk of T2DM and the lower risk of MVCDs in the Han Chinese population.