Maternal ethnicity, paternal ethnicity, and parental ethnic discordance - Predictors of preeclampsia
Maternal ethnicity, paternal ethnicity, and parental ethnic discordance - Predictors of preeclampsia
复制标题
DOI：
10.1097/01.aog.0000164478.91731.06
复制
发表时间：
2005-07-01
影响因子：
7.2
通讯作者：
Escobar, GJ
中科院分区：
文献类型：
--
作者：
Caughey, AB;Stotland, NE;Escobar, GJ
目的：检查母亲和父亲的种族，以及父母的种族不一致与先兆子痫。方法：回顾性队列研究的所有低风险的妇女在1995年至1999年交付一个成熟的管理式医疗机构。采用单变量和多变量分析计算母亲、父亲和合并种族的先兆子痫发生率。结果：在127，544名低风险妇女中，当在控制母亲年龄、产次、教育和胎龄的多变量模型中检查母亲种族时，我们发现非裔美国人的先兆子痫发生率较高（5.2%;比值比[OR] 1.41，95%置信区间[CI] 1.25-1.62）女性，拉丁裔女性更低（4.0%; OR 0.90，95% CI 0.84-0.97）和亚洲女性（3.5%; OR 0.79，95% CI 0.72-0.88），与白色女性相比，所有结果均具有统计学显著性。然而，当单独控制父亲种族时，亚裔妇女中先兆子痫发生率的差异消失，非裔美国人母亲种族的影响略有增加（OR 1.49，95%CI 1.33-1.72），发现亚裔父亲与先兆子痫发生率最低相关（3.2%; OR 0.76，95%CI 0.68-0.85）。此外，父母种族不一致与先兆子痫的发病率增加（OR 1.13，95%CI 1.02-1.26）。结论：我们发现，先兆子痫的发病率与亚洲父亲的种族较低。我们还发现，父亲和母亲的种族不同与先兆子痫的发病率增加有关。对于每1,000例妊娠，在亚洲父亲的背景下，先兆子痫的病例减少约10例，在父母种族不一致的背景下，先兆子痫的病例增加5例。这些差异可能有助于进一步调查先兆子痫的原因。
Objective: To examine the association of maternal and paternal ethnicity as well as parental ethnic discordance with preeclampsia.Methods: Retrospective cohort study of all low-risk women delivered from 1995 to 1999 within a mature managed care organization. Rates of preeclampsia were calculated for maternal, paternal, and combined ethnicity using both univariate and multivariate analyses.Results: Among the 127,544 low-risk women, when examining maternal ethnicity in a multivariate model controlling for maternal age, parity, education, and gestational age, we found that the rates of preeclampsia were higher among African American (5.2%; odds ratio [OR] 1.41, 95% confidence interval [CI] 1.25-1.62) women and lower among Latina (4.0%; OR 0.90, 95% CI 0.84-0.97) and Asian women (3.5%; OR 0.79, 95% CI 0.72-0.88), with all results being statistically significant as compared with white women. When paternal ethnicity was controlled for separately, however, the difference in the rate of preeclampsia among Asian women disappeared, the effect of African-American maternal ethnicity increased slightly (OR 1.49, 95% CI 1.33-1.72), and Asian paternity was found to be associated with the lowest rate of preeclampsia (3.2%; OR 0.76, 95% CI 0.68-0.85). Further, parental ethnic discordance was associated with an increase in the rate of preeclampsia (OR 1.13, 95% Cl 1.02-1.26).Conclusion: We found that rates of preeclampsia were lower with Asian paternal ethnicity. We also found that having a differing paternal and maternal ethnicity was associated with increased rates of preeclampsia. For every 1,000 pregnancies, there would be approximately 10 fewer cases of preeclampsia in the setting of Asian paternity and 5 more cases of preeclampsia in the setting of parental ethnic discordance. These differences may be useful in further investigation of the cause of preeclampsia.