Myocardial depression in sepsis
Myocardial depression in sepsis
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DOI：
10.1097/shk.0b013e3181818617
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发表时间：
2008-01-01
期刊：
影响因子：
3.1
通讯作者：
Knobel, Elias
中科院分区：
文献类型：
--
作者：
Fernandes, Constantino Jose, Jr.;Akamine, Nelson;Knobel, Elias
自古希腊以来，我们就知道人类疾病的病理生理学依赖于血液传播的体液因素。脓毒症心肌抑制就是这种情况，其相关的发病率和死亡率在过去几十年中保持不变。尽管对可能涉及的机制的了解越来越多，但我们对这种严重情况的理解仍处于起步阶段。脓毒症引起的心肌功能障碍的真实的起源一直存在争议，它被归因于炎症介质、NO生成、间质性心肌炎、冠状动脉缺血、钙转运、内皮素受体拮抗剂和细胞凋亡。虽然尚未完全了解，心肌损伤/抑郁症仍然是一个挑战，重症监护医生。
Since the ancient Greeks, we have learned that the pathophysiology of the human diseases relies on blood-borne humoral factors. This was the case with the sepsis myocardial depression, whose associated morbidity and mortality remained untouched during the last decades. Despite the growing knowledge of the possible involved mechanisms, our understanding of this serious condition is still in its infancy. Controversies have surrounded the real origin of septic-induced myocardial dysfunction, and it has been ascribed to inflammatory mediators, NO generation, interstitial myocarditis, coronary ischemia, calcium trafficking, endothelin receptor antagonist, and apoptosis. Although not fully understood, myocardial injury/depression remains a challenge for critical care practitioners.