In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy.
In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy.
复制标题
使用空间频域光谱在体内分离黑色素对不同皮肤类型的潜在血流动力学的影响。
DOI：
10.1117/1.jbo.21.5.057001
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发表时间：
2016
影响因子：
3.5
通讯作者：
Durkin,AnthonyJ
中科院分区：
文献类型：
--
作者：
Saager,RolfB;Sharif,Ata;Kelly,KristenM;Durkin,AnthonyJ
皮肤是一个高度结构化的组织，这引起了人们的关注，即表皮黑色素引起的皮肤色素沉着是否会混淆潜在血液动力学的准确测量。使用静脉和动脉袖带闭塞作为诱导差分血流动力学扰动的手段，除了分层模型方法外，我们还提出了仅限于可见光或近红外光谱的分析。黑色素的影响，跨越菲茨帕特里克皮肤类型I到V，对皮肤血液动力学的潜在估计的这些光谱区域进行了评估。分层模型在黑色素和血流动力学之间提供最小的串扰，并能够消除测量组织氧合估计和皮肤光型之间的问题相关性。
Skin is a highly structured tissue, raising concerns as to whether skin pigmentation due to epidermal melanin may confound accurate measurements of underlying hemodynamics. Using both venous and arterial cuff occlusions as a means of inducing differential hemodynamic perturbations, we present analyses of spectra limited to the visible or near-infrared regime, in addition to a layered model approach. The influence of melanin, spanning Fitzpatrick skin types I to V, on underlying estimations of hemodynamics in skin as interpreted by these spectral regions are assessed. The layered model provides minimal cross-talk between melanin and hemodynamics and enables removal of problematic correlations between measured tissue oxygenation estimates and skin phototype.