Intradermal capsaicin inhibits lumbar dorsal horn neuronal responses to colorectal distention.
Intradermal capsaicin inhibits lumbar dorsal horn neuronal responses to colorectal distention.
复制标题
皮内辣椒素抑制腰背角神经元对结直肠扩张的反应。
DOI：
10.1097/01.wnr.0000070825.57864.db
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Al-Chaer,ElieD
中科院分区：
文献类型：
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作者：
Kawasaki,Motohiro;Al-Chaer,ElieD
本研究的目的是检查皮肤炎症对内脏会聚背角神经元对分级结直肠扩张（CRD）和皮肤机械刺激反应的影响。在感受野（RF）或同侧和对侧前爪皮内注射辣椒素诱导皮肤炎症之前和之后 50 分钟，记录大鼠脊髓腰背角单个内脏神经元对 CRD 和皮肤刺激的反应。在 RF 中注射辣椒素可引起背角神经元自发活动的增加、RF 大小的扩大并促进其对皮肤刺激的反应。在射频中心注射可以减弱对有害 CRD 的反应。前爪注射辣椒素导致对 CRD 的反应显着降低，但对皮肤刺激的反应没有显着降低。这些结果表明，由皮肤炎症引起的抑制作用可以调节背角神经元对 CRD 的反应，与其对皮肤机械刺激反应的影响无关。 NeuroReport 14：985–989© 2003 Lippincott Williams & Wilkins。
The purpose of this study was to examine the effect of cutaneous inflammation on the responses of viscerosomatic convergent dorsal horn neurons to graded colorectal distension (CRD) and cutaneous mechanical stimulation. Responses of single viscerosomatic neurons in the lumbar dorsal horn of the rat spinal cord to CRD and to cutaneous stimuli were recorded before and 50 min after cutaneous inflammation induced by intradermal injection of capsaicin in the receptive field (RF) or in the ipsilateral and contralateral forepaw. Capsaicin injection in the RF induced an increase in the spontaneous activity of dorsal horn neurons, an expansion in the size of their RF and facilitated their responses to cutaneous stimuli. An injection placed in the center of the RF attenuated the responses to noxious CRD. Capsaicin injection in the forepaw caused a significant decrease in the responses to CRD but not to cutaneous stimuli. These results indicate that the inhibitory effects, evoked by cutaneous inflammation, can modulate the responses of dorsal horn neurons to CRD, independent of its effect on the responses to cutaneous mechanical stimuli. NeuroReport 14: 985–989© 2003 Lippincott Williams & Wilkins.