Group Living and Male Dispersal Predict the Core Gut Microbiome in Wild Baboons
Group Living and Male Dispersal Predict the Core Gut Microbiome in Wild Baboons
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DOI：
10.1093/icb/icx046
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发表时间：
2017-10-01
影响因子：
2.6
通讯作者：
Archie, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Grieneisen, Laura E.;Livermore, Josh;Archie, Elizabeth A.
哺乳动物肠道微生物组在宿主的生理、代谢和整体健康中起着深远的作用。然而，生物学家对驱动肠道微生物组成个体间异质性的力量，特别是宿主社会环境的作用，只有初步的了解。在这里，我们使用了来自生活在两个社会群体中的78只野生黄狒狒（Papio cynocephalus）的178个样本，以测试宿主的社会环境，包括群体生活，群体内的社会互动以及社会群体之间的转移（例如，扩散）预测肠道微生物α和β多样性的个体间变化。我们还测试了社会影响是否不同的流行的“核心”肠道微生物类群，这被认为是提供主要功能的主机，与罕见的“非核心”微生物，这可能代表相对短暂的环境收购。与之前的研究相同，我们发现每个社会群体都有一个独特的肠道微生物群落。这些差异包括非核心和核心肠道微生物类群，这表明这些影响不仅仅是由最近的肠道微生物暴露引起的。在社会群体中，亲密的梳理伙伴具有更多相似的核心微生物组，但不是非核心微生物组，而不是很少相互梳理的个体，即使控制梳理伙伴之间的亲属关系和饮食相似性。最后，为了支持肠道微生物组可以被当前社会环境改变的观点，我们发现移民男性在特定社会群体中生活的时间越长，他的肠道微生物组就越接近该群体长期居民的肠道微生物组。总之，这些结果揭示了宿主的社会背景在塑造肠道微生物组方面的重要性，并为男性传播的微生物组相关后果提供了新的线索。
The mammalian gut microbiome plays a profound role in the physiology, metabolism, and overall health of its host. However, biologists have only a nascent understanding of the forces that drive inter-individual heterogeneity in gut microbial composition, especially the role of host social environment. Here we used 178 samples from 78 wild yellow baboons (Papio cynocephalus) living in two social groups to test how host social context, including group living, social interactions within groups, and transfer between social groups (e.g., dispersal) predict inter-individual variation in gut microbial alpha and beta diversity. We also tested whether social effects differed for prevalent "core" gut microbial taxa, which are thought to provide primary functions to hosts, versus rare "non-core" microbes, which may represent relatively transient environmental acquisitions. Confirming prior studies, we found that each social group harbored a distinct gut microbial community. These differences included both non-core and core gut microbial taxa, suggesting that these effects are not solely driven by recent gut microbial exposures. Within social groups, close grooming partners had more similar core microbiomes, but not non-core microbiomes, than individuals who rarely groomed each other, even controlling for kinship and diet similarity between grooming partners. Finally, in support of the idea that the gut microbiome can be altered by current social context, we found that the longer an immigrant male had lived in a given social group, the more closely his gut microbiome resembled the gut microbiomes of the group's long-term residents. Together, these results reveal the importance of a host's social context in shaping the gut microbiome and shed new light onto the microbiome-related consequences of male dispersal.