Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases
Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases
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DOI：
10.4103/1673-5374.265543
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发表时间：
2019-09
影响因子：
6.1
通讯作者：
Rubaiya Tabassum;N. Y. Jeong;Junyang Jung
中科院分区：
文献类型：
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作者：
Rubaiya Tabassum;N. Y. Jeong;Junyang Jung
硫化氢是一种抗氧化剂分子，具有广泛的抗氧化应激生物效应。平衡的氧化应激对于维持生物系统中的细胞功能也至关重要，其中活性氧是氧化应激的主要来源。当正常的氧化还原平衡受到干扰时，脱氧核糖核酸、脂质和蛋白质分子会在病理条件下被氧化，例如糖尿病，导致糖尿病周围神经病变。在糖尿病引起的糖尿病周围神经病变中，由于高血糖，胰腺β细胞（β细胞）表现出对胰岛素分泌的抵抗。结果，神经元细胞中的葡萄糖代谢受到干扰，无法提供适当的细胞信号传导途径。脑神经病变不仅会发生糖尿病周围神经病变，还会发生其他中枢损害。对患有阿尔茨海默病、帕金森病和肌萎缩侧索硬化症的 1 型糖尿病患者的神经学研究表明，由于高血糖 (HbA1c) 水平和认知功能较差，中枢神经系统发生了变化。氧化应激在抑制大脑功能所必需的胰岛素信号传导方面发挥着重要作用。硫化氢对氧化应激表现出抗氧化作用，其中胱硫醚β合酶、胱硫醚γ裂解酶和3-巯基丙酮酸硫转移酶是硫化氢的内源性来源。本文旨在探讨氧化应激条件下糖尿病引起的糖尿病周围神经病变及其他神经合并症的发病机制以及硫化氢的抗氧化作用。
Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus-induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell (β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes in the central nervous system because high blood glucose levels (HbA1c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus-induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide.