Impacts of inter-trial interval duration on a computational model of sign-tracking vs. goal-tracking behaviour.
Impacts of inter-trial interval duration on a computational model of sign-tracking vs. goal-tracking behaviour.
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试验间间隔持续时间对符号跟踪与目标跟踪行为的计算模型的影响。
DOI：
10.1007/s00213-019-05323-y
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发表时间：
2019
影响因子：
3.4
通讯作者：
Khamassi,Mehdi
中科院分区：
文献类型：
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作者：
Cinotti,François;Marchand,AlainR;Roesch,MatthewR;Girard,Benoît;Khamassi,Mehdi
在巴甫洛夫条件反射的背景下，两种类型的行为可能在群体中出现（Flagel等人，Nature，469（7328）：53-57，2011）。动物可以选择参与条件刺激（CS），这是一种被称为符号追踪（ST）的行为，它对多巴胺抑制的获取很敏感，或者参与最终将提供奖励或非条件刺激（US）的食物杯，这是一种被称为目标追踪（GT）的行为，它只依赖于多巴胺的表达。Lesaint等人先前的工作（PLoS Comput Biol，10（2），2014）为这些现象提供了计算解释，并预测改变试验间隔（ITI）的持续时间将改变人群中的相对ST-GT比例以及阶段性多巴胺反应。最近的一项研究验证了这一预测，但也发现了试验中ST和GT行为的丰富变化，超出了原始计算模型。在本文中，我们提供了一个计算的角度来看，这些新的结果。
In the context of Pavlovian conditioning, two types of behaviour may emerge within the population (Flagel et al. Nature, 469(7328): 53–57, 2011). Animals may choose to engage either with the conditioned stimulus (CS), a behaviour known as sign-tracking (ST) which is sensitive to dopamine inhibition for its acquisition, or with the food cup in which the reward or unconditioned stimulus (US) will eventually be delivered, a behaviour known as goal-tracking (GT) which is dependent on dopamine for its expression only. Previous work by Lesaint et al. (PLoS Comput Biol, 10(2), 2014) offered a computational explanation for these phenomena and led to the prediction that varying the duration of the inter-trial interval (ITI) would change the relative ST-GT proportion in the population as well as phasic dopamine responses. A recent study verified this prediction, but also found a rich variance of ST and GT behaviours within the trial which goes beyond the original computational model. In this paper, we provide a computational perspective on these novel results.