Perspective: The physics, diagnostics, and applications of atmospheric pressure low temperature plasma sources used in plasma medicine
Perspective: The physics, diagnostics, and applications of atmospheric pressure low temperature plasma sources used in plasma medicine
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DOI：
10.1063/1.4993710
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发表时间：
2017-07-14
影响因子：
3.2
通讯作者：
Keidar, M.
中科院分区：
文献类型：
--
作者：
Laroussi, M.;Lu, X.;Keidar, M.
几十年来，低温等离子体一直用于各种等离子体处理应用。但直到最近三十年左右，在大气压下以可靠和稳定的方式产生这种等离子体的源才变得更加普遍。首先，在 20 世纪 80 年代末，介质阻挡放电被用来在大气压下产生相对较大体积的扩散等离子体。然后，在 2000 年代初期，人们开发出了可以在环境空气中发射冷等离子体羽流的等离子射流。对这两种方法进行了大量的实验和建模工作，并且阐明了控制这些源的许多物理原理。从 20 世纪 90 年代中期开始，低温等离子体放电已被用作化学反应物质的来源，这些化学反应物质可以被传输以与生物介质、细胞和组织相互作用，并引发有影响力的生物效应。然而，血浆影响细胞的许多生化途径仍不清楚。这种情况正在迅速改变，因为今天被称为“等离子体医学”的领域在过去几年中经历了指数级增长，这要归功于全球研究界从事基础和应用研究，涉及使用冷等离子体灭活细菌、牙科应用、伤口愈合和破坏癌细胞/肿瘤。从这个角度来看，作者首先回顾了血浆医学中使用的主要血浆源的物理学和诊断学。然后，简要描述了它们的生物医学应用。最后，作者给出了对该领域现状和未来前景的个人评估。由 AIP 出版社出版。
Low temperature plasmas have been used in various plasma processing applications for several decades. But it is only in the last thirty years or so that sources generating such plasmas at atmospheric pressure in reliable and stable ways have become more prevalent. First, in the late 1980s, the dielectric barrier discharge was used to generate relatively large volume diffuse plasmas at atmospheric pressure. Then, in the early 2000s, plasma jets that can launch cold plasma plumes in ambient air were developed. Extensive experimental and modeling work was carried out on both methods and much of the physics governing such sources was elucidated. Starting in the mid-1990s, low temperature plasma discharges have been used as sources of chemically reactive species that can be transported to interact with biological media, cells, and tissues and induce impactful biological effects. However, many of the biochemical pathways whereby plasma affects cells remain not well understood. This situation is changing rather quickly because the field, known today as "plasma medicine," has experienced exponential growth in the last few years thanks to a global research community that engaged in fundamental and applied research involving the use of cold plasma for the inactivation of bacteria, dental applications, wound healing, and the destruction of cancer cells/tumors. In this perspective, the authors first review the physics as well as the diagnostics of the principal plasma sources used in plasma medicine. Then, brief descriptions of their biomedical applications are presented. To conclude, the authors' personal assessment of the present status and future outlook of the field is given. Published by AIP Publishing.