Direct C-H/C-X Coupling Methodologies Mediated by Pd/Cu or Cu: An Examination of the Synthetic Applications and Mechanistic Findings
Direct C-H/C-X Coupling Methodologies Mediated by Pd/Cu or Cu: An Examination of the Synthetic Applications and Mechanistic Findings
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DOI：
10.2174/157017911794407656
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发表时间：
2011-02-01
影响因子：
1.8
通讯作者：
Fairlamb, Ian J. S.
中科院分区：
文献类型：
--
作者：
De Ornellas, Sara;Storr, Thomas E.;Fairlamb, Ian J. S.
有机铜化学长期以来被认为是导致产生C-C、C-O、C-N、C-S和C-X键的强大合成方法。本文综述了非官能芳烃催化和化学计量有机金属反应的研究进展。G.本文综述了铜和铜/钯混合体系促进的芳香族C-X/C-H键偶联反应的背景、应用和最新进展。这些反应的疗效和范围进行了讨论，并将不同的方法置于上下文。机制的考虑和证据在审查中的适当结合点强调。
Organocopper chemistry has long been known to be powerful synthetic methodology leading to the generation of C-C, C-O, C-N, C-S and C-X bonds. Advances in catalytic and stoichiometric organometallic reactions for the formation of C-C bonds from unfunctionalised arenes, e. g. by activation-functionalisation of a C-H bond, provides diverse and applicable reaction conditions for direct functionalisation.This review covers the background, applications and recent advances made in the area of aromatic C-X/C-H-bond couplings promoted by copper and copper/palladium mixed systems. The efficacy and scope of these reactions are discussed and the different methodologies are placed into context. Mechanistic considerations and evidence are highlighted at appropriate junctures in the review.