SINUSOIDAL EMBOLIZATION - IMPACT OF IODIZED OIL ON HEPATIC MICROCIRCULATION
SINUSOIDAL EMBOLIZATION - IMPACT OF IODIZED OIL ON HEPATIC MICROCIRCULATION
复制标题
DOI：
10.1016/s1051-0443(94)71629-8
复制
发表时间：
1994-11-01
影响因子：
2.9
通讯作者：
WALLACE, S
中科院分区：
文献类型：
--
作者：
KAN, ZX;WALLACE, S
目的：探讨肝癌化疗栓塞术中使用的碘化油对肝脏微循环的影响，并测定微循环恢复所需的时间。材料和方法：将碘化油分别以0.1、0.2、0.4mL/kg剂量注入大鼠肝动脉(n=63)。在手术过程中和手术后即刻以及第1、3、7、15、30和60天进行活体显微镜检查。对照组大鼠接受相同的显微镜操作。结果：注射碘化油后微循环发生变化。注入肝动脉的油进入门静脉，流入肝窦，形成不完全的肝窦栓塞。肝窦循环在注射0.1、0.2、0.4m L/kg油后3、7、30d恢复。结论：大鼠肝脏对油的耐受性良好。尽管微循环发生了变化，恢复时间呈非线性，但微循环完全恢复，即使在0.4mL/kg剂量下也是如此。
PURPOSE: To determine the effects of iodized oil, which is used in chemoembolization of liver cancer, on hepatic microcirculation and to measure the time required for recovery of microcirculation.MATERIALS AND METHODS: Iodized oil was injected in 0.1-, 0.2-, and 0.4-mL/kg doses into the hepatic artery in three groups of rats (n = 63). In vivo microscopy was performed during and immediately after the procedure and on days 1, 3, 7, 15, 30, and 60. A control group of rats underwent identical microscopy procedures.RESULTS: Changes in microcirculation occurred after injections with iodized oil. Oil injected into the hepatic artery entered the portal vein and flowed into the sinusoids to create an incomplete sinusoidal embolization. Recovery of the sinusoidal circulation occurred 3, 7, and 30 days after injections of 0.1, 0.2, and 0.4 mL/kg of oil, respectively.CONCLUSIONS: The liver tolerated oil embolization well. Despite the changes in microcirculation and a nonlinear recovery time, the microcirculation completely recovered, even with a 0.4-mL/kg dose.