Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing
Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing
复制标题
DOI：
10.1128/aac.48.8.3122-3126.2004
复制
发表时间：
2004-08-01
影响因子：
4.9
通讯作者：
Shafer, RW
中科院分区：
文献类型：
--
作者：
Rhee, SY;Liu, T;Shafer, RW
在来自4,183人的6,156个序列的样本中，蛋白酶抑制剂、核苷逆转录酶（RT）抑制剂和非核苷RT抑制剂突变的前30种模式分别占耐药突变序列的55%、46%和66%。这些常见模式的表型和临床意义的表征可能会导致改善治疗建议的大部分患者的抗逆转录病毒治疗失败。
In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.