EFFECTS OF OBESITY ON RESPIRATORY-FUNCTION
EFFECTS OF OBESITY ON RESPIRATORY-FUNCTION
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DOI：
10.1164/arrd.1983.128.3.501
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
WASSERMAN, K
中科院分区：
文献类型：
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作者：
RAY, CS;SUE, DY;WASSERMAN, K
Obesity, because it alters the relationship between the lungs, chest and diaphragm, apparently alters respiratory function. Massively obese but otherwise normal, nonsmoking, young adults (43) were studied with spirometry, lung volume measurement by N washout and single-breath diffusing capacity for CO (DLCO). Changes in respiratory function were of 2 types, those that changed in proportion to degree of obesity, expiratory reserve volume (ERV) and DLCO, and those that changed only with extreme obesity, vital capacity, total lung capacity and maximal voluntary ventilation. When compared with commonly used predicting equations, mean values of subjects grouped by degree of obesity were very close to predicted values, except in those with extreme obesity in whom weight (kg)/height (cm) exceeded 1.0. In 29 subjects who lost a mean of 56 kg, significant increases in vital capacity, ERV and maximal voluntary ventilation were found along with a significant decrease in DLCO. Because most subjects fell within the generally accepted 95% confidence limits for the predicted values, obesity does not usually preclude use of usual predictors. An abnormal pulmonary function test value is apparently caused by intrinsic lung disease and not by obesity, except in those with extreme obesity.
