FACTORS THAT PREDICT INDIVIDUAL VULNERABILITY TO AMPHETAMINE SELF-ADMINISTRATION
FACTORS THAT PREDICT INDIVIDUAL VULNERABILITY TO AMPHETAMINE SELF-ADMINISTRATION
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DOI：
10.1126/science.2781295
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发表时间：
1989-09-29
期刊：
影响因子：
56.9
通讯作者：
SIMON, H
中科院分区：
文献类型：
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作者：
PIAZZA, PV;DEMINIERE, JM;SIMON, H
临床观察表明，对药物成瘾性的反应存在相当大的个体差异。在成瘾的动物模型中，需要考虑到这种个体差异。像人类一样，只有一些老鼠容易自我管理低剂量的精神兴奋剂。可以根据动物对环境或药理学挑战的反应来识别处于风险中的个体动物。这种发展自我给药的倾向可以通过反复使用安非他明治疗来诱导。这些结果可能有助于阐明在大鼠和人类中观察到的成瘾倾向的神经生物学基础。
Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.