Basilar and middle cerebral artery reactivity in patients with migraine
Basilar and middle cerebral artery reactivity in patients with migraine
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DOI：
10.1111/j.1526-4610.2004.04006.x
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发表时间：
2004-01-01
期刊：
影响因子：
5
通讯作者：
Provinciali, L
中科院分区：
文献类型：
--
作者：
Silvestrini, M;Baruffaldi, R;Provinciali, L
背景。据报道，偏头痛可能是缺血性中风的危险因素。这种关联背后的机制尚不清楚。目的：评估偏头痛患者前后循环对高碳酸血症的脑血管反应性，因为在各种临床条件下，脑血管反应性降低与卒中易感性相关。-应用经颅多普勒超声技术，对15例对照组和30例偏头痛患者（15例有先兆和15例无先兆）在无发作期间的大脑中动脉和基底动脉呼吸暂停期间的流速变化进行测量。脑血管反应性是用屏气指数来评估的，该指数是用正常吸气后记录的平均流速增加百分比除以其持续时间（以秒为单位）来计算的。-患者与对照组脑中动脉血管反应性相似，先兆偏头痛患者基底动脉血管反应性明显低于其他两组(P
Background.-Migraine has been reported as a possible risk factor for ischemic stroke. The mechanisms underlying this association are unknown.Objective.-To evaluate cerebrovascular reactivity to hypercapnia in the anterior and posterior circulation of patients with migraine, as reduced cerebrovascular reactivity is associated with a predisposition to stroke in various clinical conditions.Methods.-Using transcranial Doppler ultrasonography, changes in flow velocity during apnea were measured in both middle cerebral arteries and in the basilar artery of 15 control subjects and 30 patients with migraine (15 with aura and 15 without aura) during an attack-free period. Cerebrovascular reactivity was evaluated using the breath-holding index, which is calculated by dividing the percent increase in mean flow velocity recorded during a breath-holding episode by its duration (in seconds) after a normal inspiration.Results.-Vascular reactivity in the middle cerebral arteries was similar in patients and controls and significantly lower in the basilar artery of patients with migraine with aura compared with the other 2 groups (P