Effect of Vitamin D Supplementation on Body Composition and Physical Fitness in Healthy Adults: A Double-Blind, Randomized Controlled Trial.
Effect of Vitamin D Supplementation on Body Composition and Physical Fitness in Healthy Adults: A Double-Blind, Randomized Controlled Trial.
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补充维生素 D 对健康成人身体成分和体能的影响：双盲、随机对照试验。
DOI：
10.1159/000504873
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发表时间：
2019
影响因子：
3.9
通讯作者：
Cao Zhen-Bo
中科院分区：
文献类型：
--
作者：
Sun Xiaomin;Tanisawa Kumpei;Zhang Yuping;Ito Tomoko;Oshima Satomi;Higuchi Mitsuru;Cao Zhen-Bo
本研究旨在阐明1年的维生素d3补充是否对健康成人的身体成分和体质有直接影响。方法：95名参与者以双盲方式随机接受每天420 IU维生素d3 （n= 48）或安慰剂（n= 47） 1年。测定瘦体重和体脂百分比。身体健康包括手握力、腿伸长力和心肺健康（CRF）。采用ELISA试剂盒检测血清25-羟基维生素D （25[OH]D）和1,25-二羟基维生素D （1,25[OH]2D）浓度。结果：补充维生素d3 1年后，血清25(OH)D和（1,25[OH]2D）浓度分别显著增加约11.2±9.2 ng/mL （p相互作用<0.001）和7.0±7.8 pg/mL （p相互作用<0.001）。干预1年后，维生素D组瘦体重从43.8±9.6 kg显著增加到44.3±9.8 kg，而安慰剂组无变化（从42.6±8.9 kg到42.4±8.9 kg）。此外，未观察到治疗对其他身体成分和体质指标的影响。结论：一年的维生素D补充有效地改善了健康成年人的瘦体重，但没有改善肌肉力量和CRF。
Introduction:This study aimed to clarify whether 1 year of vitamin D3supplementation has a direct effect on body composition and physical fitness in healthy adults.Methods:Ninety-five participants randomly received either 420 IU vitamin D3per day (n= 48) or placebo (n= 47) in a double-blind manner for 1 year. Lean body mass and percentage body fat were determined. Physical fitness including hand grip strength, leg extension power and cardiorespiratory fitness (CRF) were assessed. Serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) concentrations were assessed using ELISA kits.Results:Serum 25(OH)D and (1,25[OH]2D) concentrations significantly increased by approximately 11.2 ± 9.2 ng/mL (pinteraction<0.001)and 7.0 ± 7.8 pg/mL (pinteraction<0.001) after 1 year of vitamin D3supplementation respectively. Lean body mass significantly increased from 43.8 ± 9.6 to 44.3 ± 9.8 kg in vitamin D group, while no change was observed in placebo group (from 42.6 ± 8.9 to 42.4± 8.9 kg) after 1 year intervention. Furthermore, no treatment effects on other indicators of body composition and physical fitness were observed.Conclusions:One year of vitamin D supplementation effectively improves lean body mass, but not muscle strength and CRF in healthy adults.