Short report:: The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans
Short report:: The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans
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DOI：
10.4269/ajtmh.2008.78.806
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发表时间：
2008-05-01
影响因子：
3.3
通讯作者：
Schwartz, Ira
中科院分区：
文献类型：
--
作者：
Dykhuizen, Daniel E.;Brisson, Dustin;Schwartz, Ira
伯氏疏螺旋体（Borrelia burgdorferi）（导致莱姆病的细菌）的谱系可以通过外表面蛋白C（ospC）基因座处的不同等位基因来表征。由ospC基因型标记的谱系已显示在不同物种的哺乳动物（包括人类）中具有差异性侵袭性;基因型A、B、1和K有效地传播到人类血液和脑脊液中。在这份报告中，我们扩展了从人类血液中分离的基因型样本，包括基因型N，H，C，M和D，并根据其从蜱传播到人类血液的概率对每种基因型进行排名。我们的结果表明，只有部分基因型的B。存在于蜱中的伯氏菌在人类中传播的倾向很高。
Lineages of Borrelia burgdorferi, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (ospC) locus. The lineages marked by ospC genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, 1, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of B. burgdorferi present in ticks have a high propensity to disseminate in humans.