A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles
A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles
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DOI：
10.1021/jo034981k
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发表时间：
2003-10-03
影响因子：
3.6
通讯作者：
Hursthouse, MB
中科院分区：
文献类型：
--
作者：
Dobbs, AP;Guesné, SJJ;Hursthouse, MB
甲硅烷基化高烯丙醇、硫醇或胺与醛或环氧化物的多功能且高产率的三氯化铟介导的环化反应被描述为制备一系列不饱和杂环的快速途径。观察到的优异的非对映选择性提供了一种范围广泛且通用的方法。
A versatile and high-yielding indium trichloride mediated cyclization reaction of silylated homoallylic alcohols, thiols, or amines with aldehydes or epoxides is described as a rapid route to a range of unsaturated heterocycles. The excellent diastereoselectivity observed offers a method of wide scope and generality.