From mice and MOF: rodent models, immune modulation, and outcome in the critically ill.
From mice and MOF: rodent models, immune modulation, and outcome in the critically ill.
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来自小鼠和 MOF：啮齿动物模型、免疫调节和重症患者的结果。
DOI：
10.1097/01.ccm.0000202439.45624.e8
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发表时间：
2006
影响因子：
8.8
通讯作者：
K. Reinhart
中科院分区：
文献类型：
--
作者：
M. Bauer;K. Reinhart
在生理应激之后，生物体启动所谓的急性期反应，其涉及炎症介质、激素（甲状腺激素、类固醇、性激素、胰岛素）和自主神经系统。对衰竭循环的药理学支持已经争论了40年，并且近世纪来一直使用儿茶酚胺来支持它（1，2）。这些生理性神经体液介质必须适应陆地生活，例如，从子宫内到子宫外生活所需的大量儿茶酚胺激增，其中脐带儿茶酚胺水平与围产期应激相关（3）。实际上，有几种药物具有不同的药理学谱。在儿茶酚胺类药物中，多巴胺、多巴酚丁胺、肾上腺素和去甲肾上腺素是最常用的药物。SOAP计划是欧洲200个重症监护室（ICU）在2周内收治的所有患者的“快照”，最近发表在期刊上（3a）。在本期《重症监护医学》中，Sakr博士及其同事（4）使用数据库进行了一项针对血流动力学支持的二次分析。他们隔离接受儿茶酚胺治疗的患者，并根据接受的药物分析他们的生存情况。SOAP调查的其他方面发表为摘要（5-8）或评估特定点（如肺动脉导管）的文章（9）。
Following a physiologic stress, the organism initiates the so-called acute phase response, which involves inflammatory mediators, hormones (thyroid hormones, steroids, sexual hormones, insulin), and the autonomic nervous system. Pharmacologic support of the failing circulation has been debated for 40 yrs, and catecholamines have been used for near a century to support it (1, 2). These physiologic neurohumoral mediators are mandatory to be adapted to terrestrial life as, for example, the massive catecholamine surge necessary to adapt from an intrauterine to an extrauterine life in which umbilical cord catecholamine levels correlate with perinatal stress (3). Actually, several agents are available with different pharmacologic spectra. Among catecholamines, dopamine, dobutamine, epinephrine, and norepinephrine are the most used drugs.The SOAP initiative is a “snapshot” of all patients admitted to 200 intensive care units (ICUs) across Europe during 2 wks, and has recently been published in the journal (3a). In the present issue of Critical Care Medicine, Dr. Sakr and colleagues (4) present a secondary analysis focusing on hemodynamic support using the database. They isolated patients receiving catecholamines and analyzed their survival according to the drug received. Other aspects from the SOAP survey were published as abstracts (5–8) or articles assessing specific points such as the pulmonary artery catheter (9).
影响因子：
4.4
作者：
Mark K. Eskandari;G. Bolgos;Christopher J. Miller;D. Nguyen;L. Deforge;D. Remick
通讯作者：
Mark K. Eskandari;G. Bolgos;Christopher J. Miller;D. Nguyen;L. Deforge;D. Remick