Epidermal Stem Cells in Wound Healing and Regeneration
Epidermal Stem Cells in Wound Healing and Regeneration
复制标题
表皮干细胞在伤口愈合和再生中的作用
DOI：
10.1155/2020/9148310
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发表时间：
2020
影响因子：
4.3
通讯作者：
Julin Xie
中科院分区：
文献类型：
--
作者：
Ronghua Yang;Jingru Wang;Xiaodong Chen;Yan Shi;Julin Xie
皮肤干细胞分布在表皮基底层和毛囊中，是皮肤发育、代谢和损伤修复的重要细胞来源。目前，对表皮干细胞在细胞和分子水平上的研究取得了很大进展。据报道，干细胞移植可促进皮肤愈合、内皮细胞转化和血管形成。局部干细胞也可以转化为角质形成细胞、皮脂腺和其他皮肤相关组织。然而，表皮干细胞对创面愈合和再生的作用机制尚不完全清楚。本文就表皮干细胞的生物学特性及其在创面愈合和组织再生中的临床应用作一综述。并进一步探讨了其作用机理和今后的发展方向。
Skin stem cells distributed in the basal layer of the epidermis and hair follicles are important cell sources for skin development, metabolism, and injury repair. At present, great progress has been made in the study of epidermal stem cells at the cellular and molecular levels. Stem cell transplantation is reported to promote skin healing, endothelial cell transformation, and vascular formation. Local stem cells can also be transformed into keratinocytes, sebaceous gland, and other skin-associated tissues. However, the mechanism of action of epidermal stem cells on wound healing and regeneration is not completely clear. This review is aimed at briefly summarizing the biological characteristics of epidermal stem cells and their clinical application in wound healing and tissue regeneration. It further discussed the mechanism of action and the development direction in the future.