Cell therapies: careful translation from animals to patients.
Cell therapies: careful translation from animals to patients.
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DOI：
10.1161/strokeaha.112.679605
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发表时间：
2013-06
期刊：
影响因子：
8.3
通讯作者：
Savitz SI
中科院分区：
文献类型：
--
作者：
Savitz SI
The bone marrow is an attractive source to derive or extract cells with therapeutic activity. Several studies have shown that the marrow contains several different stem cells involved in tissue homeostasis and repair. 6 After stroke, the bone marrow releases different types of stem cells, including hematopoietic stem cells, as well as mesenchymal and endothelial progenitor cells, into the circulation. Once released into the bloodstream, some of these progenitor cells may even home to sites of ischemic injury in the brain. 6 Thus, it is hypothesized that the bone marrow may participate in brain repair by mobilizing and releasing stem cells, but this concept still requires much further study. It is unclear how exactly stem cells (and in what proportion are they released) enter the brain after injury and stimulate recovery processes.
