Functional significance of age-related differences in motor activation patterns
Functional significance of age-related differences in motor activation patterns
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DOI：
10.1016/j.neuroimage.2006.05.021
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发表时间：
2006-09-01
期刊：
影响因子：
5.7
通讯作者：
Kastrup, Andreas
中科院分区：
文献类型：
--
作者：
Riecker, Axel;Groeschel, Klaus;Kastrup, Andreas
最近的功能性磁共振成像（fMRI）研究表明，在各种认知或知觉任务中，老年人的任务相关激活增加，这可能表明有益的代偿活动可以抵消与衰老相关的结构和神经化学变化。假设运动速率的增加与运动系统功能需求的增加有关，我们使用fMRI和6个不同频率（2.0、2.5、3.0、4.0、5.0和6.0 Hz）的右手食指声节奏运动来研究一组健康的老年受试者（平均年龄668岁）与一组年轻受试者（平均年龄237岁）额外招募的大脑区域的行为意义。实际轻敲频率（F(1,14) = 0.049, P = 0.829）、轻敲间隔（F(1,14) = 0.043, P = 0.847）和错误率（F(1,14) = 0.058, P = 0.743）在两组间无显著差异，而年龄较大的被试的反应时间显著增加（F(1,14) = 281.786, P = 0.743）
Recent functional MRI (fMRI) studies have revealed an increased task-related activation in older subjects during a variety of cognitive or perceptual tasks, which may signal beneficial compensatory activity to counteract structural and neurochemical changes associated with aging. Under the assumption that incremental movement rates are associated with an increased functional demand on the motor system, we used fMRI and acoustically paced movements of the right index finger at six different frequencies (2.0, 2.5, 3.0, 4.0, 5.0 and 6.0 Hz) to investigate the behavioral significance of additionally recruited brain regions in a group of healthy, older subjects (mean age 66 8 years) compared with a group of young (mean age 23 7 years) subjects. The actual tapping frequency (F(1,14) = 0.049, P = 0.829), the tapping interval (F(1,14) = 0.043, P = 0.847), and the error rates (F(1,14) = 0.058, P = 0.743) did not differ significantly between both groups, whereas there was a significant increase in reaction time in the older subjects (F(1,14) = 281.786, P