Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population
Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population
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中国人群血管内皮生长因子A基因多态性与散发性脑动静脉畸形易感性
DOI：
10.1016/j.jocn.2010.08.025
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发表时间：
2011-04-01
影响因子：
2
通讯作者：
Zhao, Yao
中科院分区：
文献类型：
--
作者：
Chen, Hongyan;Gu, Yuxiang;Zhao, Yao
人脑动静脉畸形（BAVM）组织中血管内皮生长因子A（VEGFA）水平升高。我们进行了一项病例对照研究，以确定VEGFA基因多态性是否与散发性BAVM相关。采用MassARRAY基因分型系统对319例BAVM患者和333例对照者的9个VEGFA单核苷酸多态性（SNP）进行基因分型。我们在VEGFA基因中发现了四种单一变异（rs1547651，rs2010963，rs833069和rs3025010），其中一种单倍型ACT可能与BAVM的发生风险相关。(c)2010爱思唯尔有限公司保留所有权利。
Human brain arteriovenous malformation (BAVM) tissue contains increased levels of vascular endothelial growth factor A (VEGFA). We carried out a case-control study to determine whether polymorphisms in the VEGFA gene are associated with sporadic BAVM. Nine selected VEGFA single-nucleotide polymorphisms (SNP) were genotyped in 319 patients with BAVM and 333 controls from a Chinese population using the MassARRAY genotyping system. We found four single variants in the VEGFA gene (rs1547651, rs2010963, rs833069 and rs3025010), with one haplotype, ACT, possibly associated with the risk of developing BAVM. (c) 2010 Elsevier Ltd. All rights reserved.