Usefulness of detection of complement activation products in evaluating SLE activity
Usefulness of detection of complement activation products in evaluating SLE activity
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DOI：
10.1177/096120330000900105
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发表时间：
2000-01-01
期刊：
影响因子：
2.6
通讯作者：
Gergely, P
中科院分区：
文献类型：
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作者：
Nagy, G;Brózik, M;Gergely, P
补体激活产物，如特异性激活经典途径的Clrs-Clinh，特异性激活替代途径的C3b(Bb)P和特异性激活补体级联共同末端途径的SC5b-9，在健康供体和临床活动性和非活动性系统性红斑狼疮（SLE）患者中进行了测量。与健康对照组相比，临床不活跃SLE患者血浆C3b(Bb)P和SC5b-9水平中等，Clrs-Clinh水平明显升高。C3b(Bb)P血浆浓度最能反映疾病活动性和非活动性阶段的差异（P < 0.001），与SLEDAI的相关性最高（Rs = 0.41 P < 0.001），也是区分活动性和非活动性样品对最有用的方法。SC5b-9在活跃期和不活跃期的水平差异也有统计学意义（P = 0.007），而Clrs-Clinh的水平差异无统计学意义（P = 0.136）。SLEDAI与SC5b-9的相关性为0.3 (P = 0.015)，与Clrs-Clinh的相关性为0.21 （P = 0.089）。这些发现表明，补体激活产物的测量，特别是替代途径的测量，是SLE活性的敏感标记物，可用于临床目的。
Complement activation products, such as Clrs-Clinh, specific for the activation of the classical pathway, C3b(Bb)P, specific for the activation of the alternative pathway and SC5b-9, specific for common terminal pathway of the complement cascade, were measured in healthy donors and in patients with clinically active and inactive systemic lupus erythematosus (SLE). Plasma levels of C3b(Bb)P and SC5b-9 were moderately, those of Clrs-Clinhibitor (Clrs-Clinh) were markedly elevated in patients with clinically inactive SLE, compared with healthy controls. The difference between active and inactive stages of the disease was best reflected by C3b(Bb)P plasma concentration (P < 0.001), which also showed the highest correlation with the SLEDAI (Rs = 0.41 P < 0.001) and which was the most useful in distinguishing active and inactive sample pairs as well. The difference between SC5b-9 levels in the active and inactive stages was also significant (P = 0.007), while that of Clrs-Clinh did not differ significantly (P = 0.136). The correlation of the SLEDAI with SC5b-9 was 0.3 (P = 0.015), while with Clrs-Clinh it was 0.21 (P = 0.089). These findings suggest that the measurement of complement activation products, especially that of the alternative pathway, are sensitive markers of the activity of SLE and can be used for clinical purposes.