DENDRITIC SPINE DYSGENESIS AND MENTAL-RETARDATION
DENDRITIC SPINE DYSGENESIS AND MENTAL-RETARDATION
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DOI：
10.1126/science.186.4169.1126
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发表时间：
1974-01-01
期刊：
影响因子：
56.9
通讯作者：
PURPURA, DP
中科院分区：
文献类型：
--
作者：
PURPURA, DP
高尔基体研究显示，在核型正常的弱智儿童的皮质神经元树突上，异常长而细的棘和缺乏短而粗的棘。树突棘丢失和异常的程度似乎与年龄和发育迟缓的严重程度有关。树突状脊柱“发育不良”是发生在病因不明的深度智力迟钝的显微结构病理学的共同特征。
Golgi studies reveal abnormally long, thin spines and the absence of short, thick spines on dendrites of cortical neurons in retarded children with normal karyotypes. The degree of dendritic spine loss and abnormality appears to be related to age and the severity of developmental retardation. Dendritic spine "dysgenesis" is a common feature of the microstructural pathology that occurs in profound mental retardation of unknown etiology.