Antitumor effect of TNP-470 on glial tumors transplanted in rats.
Antitumor effect of TNP-470 on glial tumors transplanted in rats.
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TNP-470 对大鼠神经胶质瘤移植的抗肿瘤作用。
作者：
N. Isobe;Tohru Uozumi;Kaoru Kurisu;Keiichi Kawamoto
由于肿瘤的生长和增殖需要新生血管的存在，因此抗血管生成剂在临床上可用于实体瘤的治疗。以前的报告中，已经提出了TNP-470，血管生成抑制剂，对髓母细胞瘤皮下植入裸鼠的抗肿瘤作用。本研究的目的是探讨可能的抗肿瘤作用的两个模型皮下和颅内肿瘤移植到大鼠。将9-L神经胶质瘤皮下移植到Fisher 344雌性大鼠的左股骨区和左额区，然后皮下施用TNP-470。将大鼠分为两个治疗组和一个对照组。TNP-470导致9-L胶质肉瘤生长的剂量依赖性抑制，并延长治疗组的生存期。因此，TNP-470被认为是治疗恶性脑肿瘤的有效药物，尽管它会导致体重的剂量依赖性降低。
Anti-angiogenic agents were be clinically useful for the therapy of solid tumors, as the growth and proliferation of tumors require neovascularization. Previous reports have been made on the antitumor effect of TNP-470, an angiogenic inhibitor, on medulloblastomas implanted subcutaneously into nude mice. The present study was undertaken for the purpose of investigating possible antitumor effects on two model subcutaneous and intracranial tumors transplanted into rats. 9-L gliosarcomas were transplanted into the left femoral region subcutaneously and the left frontal region of Fisher 344 female rats, and the TNP-470 was then administered subcutaneously. The rats were divided into two treatment groups and a control group. TNP-470 resulted in dose-dependent inhibition of 9-L gliosarcoma growth and also prolonged survival in treatment groups. Therefore TNP-470 was considered to be effective for the treatment of malignant brain tumors, although it caused dose-dependent decreases in body weight.