A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'
A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'
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DOI：
10.1111/j.1365-2559.2007.02735.x
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发表时间：
2007-09-01
期刊：
影响因子：
6.4
通讯作者：
Nakanuma, Y.
中科院分区：
文献类型：
--
作者：
Kozaka, K.;Sasaki, M.;Nakanuma, Y.
目的：外周肝内胆管癌（peripheral hepatintracholangicarcinoma， CC）的组织发生和生物学行为尚不清楚。本研究的目的是研究外周CC（24例）与肝细胞癌（HCC， 27例）和转移性结直肠癌（MCA， 24例）的生长模式。方法和结果：肿瘤/肝周围边界分为：(i)纤维包封，（ii）压缩生长，（iii）浸润性置换。24例外周cc中有19例显示（iii）， 27例hcc中有23例显示(i)， 24例mca中有17例显示（ii）。在（iii）中，癌细胞浸润周围肝脏而未受压，肝脏支持血管结构如门静脉束继发合并到肿瘤中。在(1)和(2)中，周围肝脏被压缩，肿瘤内没有或很少有门静脉束合并。24例外周cc中有15例由类似活性胆管的癌细胞组成，这些细胞对神经细胞粘附分子（NCAM）呈阳性，NCAM是胆管增殖的标志。其余9例外周癌均为普通腺癌，NCAM阴性。结论：外周cc亚群具有浸润性替代生长模式，类似于反应性胆管并表达NCAM。“胆管癌”可能是这个亚组更好的术语。
Aims: The histogenesis and biological behaviour of peripheral intrahepatic cholangiocarcinoma (peripheral CC) remain unclarified. The aim of this study was to examine the growth pattern of peripheral CC (24 cases) in comparison with hepatocellular carcinoma (HCC, 27 cases) and metastatic colorectal adenocarcinoma (MCA, 24 cases).Methods and results: Tumour/surrounding liver borders were classified as: (i) fibrous encapsulation, (ii) compressive growth, and (iii) infiltrating replacement. Nineteen of 24 peripheral CCs showed (iii), whereas 23 of 27 HCCs showed (i) and 17 of 24 MCAs showed (ii). In (iii), carcinoma cells infiltrated the surrounding liver without compression, and hepatic supporting vascular structures such as portal tracts were secondarily incorporated into the tumour. In (i) and (ii), the surrounding liver was compressed and no or few portal tracts were incorporated within the tumour. Fifteen of 24 peripheral CCs were composed of carcinoma cells resembling reactive bile ductules and these cells were positive for neural cell adhesion molecule (NCAM), a marker of proliferating bile ductules. The remaining nine peripheral CCs were composed of ordinary adenocarcinoma and negative for NCAM.Conclusions: A subgroup of peripheral CCs with an infiltrating replacement growth pattern resembles reactive bile ductules and expresses NCAM. 'Bile ductular carcinoma' may be a better term for this subgroup.