TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection
TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection
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DOI：
10.1016/j.jhep.2019.08.024
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发表时间：
2020-01-01
影响因子：
25.7
通讯作者：
Deng, Guohong
中科院分区：
文献类型：
--
作者：
Wang, Haoliang;Luo, Heng;Deng, Guohong
背景与目的：B肝炎病毒（HBV）特异性CD 4 T细胞在慢性HBV感染患者中的作用尚不清楚。方法：通过细胞内IFN-γ和TNF-α染色，对68例慢性HBV感染和丙氨酸氨基转移酶（ALT）阳性患者的HBV特异性CD 4 T细胞进行分析。
Background & Aims: The role of hepatitis B virus (HBV)-specific CD4 T cells in patients with chronic HBV infection is not clear. Thus, we aimed to elucidate this in patients with chronic infection, and those with hepatitis B flares.Methods: Through intracellular IFN-gamma and TNF-alpha staining, HBV-specific CD4 T cells were analyzed in 68 patients with chronic HBV infection and alanine aminotransferase (ALT)