Serum dioxin and diabetes mellitus in veterans of operation ranch hand
Serum dioxin and diabetes mellitus in veterans of operation ranch hand
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DOI：
10.1097/00001648-199705000-00005
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发表时间：
1997-05-01
期刊：
影响因子：
5.4
通讯作者：
Swaby, JA
中科院分区：
文献类型：
--
作者：
Henriksen, GL;Ketchum, NS;Swaby, JA
我们研究了在越南战争期间暴露于橙子剂及其污染物2，3，7，8-四氯二苯并二恶英（二恶英）的空军退伍军人的糖尿病、葡萄糖和胰岛素水平。空军正在进行的为期20年的前瞻性流行病学研究的指标对象是牧场手行动（N = 989）的退伍军人，该部队负责1962年至1971年在越南空中喷洒除草剂。同期在东南亚服役但未参与喷洒除草剂的其他空军退伍军人作为对照（N = 1，276）。Ranch Hand组的中位血清二恶英水平为万亿分之12.2（ppt）（范围= 0-617.8 ppt），对照组的中位二恶英水平为4.0 ppt（范围= 0-10 ppt）。我们发现血糖异常[相对危险度= 1.4; 95%置信限（CL）= 1.1，1.8]，糖尿病患病率（相对风险1.5; 95% CL = 1.2，2.0），以及使用口服药物控制糖尿病（相对危险度= 2.3; 95%CL = 1.3，3.9）增加，而糖尿病发病时间减少二恶英暴露。血清胰岛素异常（相对危险度= 3.4; 95%CL = 1.9，6.1）增加二恶英暴露在非糖尿病患者。这些结果表明二恶英暴露与糖尿病、葡萄糖代谢和胰岛素产生之间存在不利关系。
We studied diabetes mellitus and glucose and insulin levels in Air Force veterans exposed to Agent Orange and its contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), during the Vietnam War. The index subjects of the Air Force's ongoing 20-year prospective epidemiologic study are veterans of Operation Ranch Hand (N = 989), the unit responsible for aerial herbicide spraying in Vietnam from 1962 to 1971. Other Air Force veterans who served in Southeast Asia during the same period but were not involved with spraying herbicides serve as Comparisons (N = 1,276). The median serum dioxin level in the Ranch Hand group was 12.2 parts per trillion (ppt) (range = 0-617.8 ppt), and the median dioxin level in the Comparison group was 4.0 ppt (range = 0-10 ppt). We found that glucose abnormalities [relative risk = 1.4; 95% confidence limits (CL) = 1.1, 1.8], diabetes prevalence (relative risk 1.5; 95% CL = 1.2, 2.0), and the use of oral medications to control diabetes (relative risk = 2.3; 95% CL = 1.3, 3.9) increased, whereas time to diabetes-onset decreased with dioxin exposure. Serum insulin abnormalities (relative risk = 3.4; 95% CL = 1.9, 6.1) increased with dioxin exposure in nondiabetics. These results indicate an adverse relation between dioxin exposure and diabetes mellitus, glucose metabolism, and insulin production.