High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects - A case-control study in multiple hospitals
High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects - A case-control study in multiple hospitals
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DOI：
10.1097/00007632-200405010-00011
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发表时间：
2004-05-01
期刊：
影响因子：
3
通讯作者：
Tanaka, H
中科院分区：
文献类型：
--
作者：
Kobashi, G;Washio, M;Tanaka, H
研究设计.进行了一项性别和年龄匹配的病例对照研究。为了促进脊柱后纵韧带骨化的早期预测、预防和治疗，作者分析了既往病史、既往体重指数和身体柔韧性，并对其他被认为是危险因素的因素进行了调整。背景资料概要。脊柱后纵韧带骨化的原因尚未详细阐明，尽管已经提出了许多可能的致病因素，包括性别、糖尿病、创伤、激素失衡和饮食习惯。方法：从69名脊柱后纵韧带骨化症患者和138名性别和年龄匹配的对照参与者没有脊柱疾病，随机选择的参与者在健康检查在一个城镇。在单因素分析后，采用逐步回归法筛选影响因素。多因素分析显示，糖尿病史、腰痛史、最大体重指数（BMI）≥ 25是脊柱后纵韧带骨化的独立危险因素。20 ~ 40岁体重过度增加、糖尿病和腰痛被认为是脊柱后纵韧带骨化的独立危险因素。后续研究，包括增加医院为基础的对照参与者和遗传多态性分析，将需要在未来。
Study Design. A sex- and age-matched case-control study was carried out.Objectives. To facilitate early prediction, prevention, and treatment of ossification of the posterior longitudinal ligament of the spine, the authors analyzed histories of past illness, past body mass indexes, and body pliableness by nature, adjusted for other factors considered to be risk factors.Summary of Background Data. The cause of ossification of the posterior longitudinal ligament of the spine has not yet been elucidated in detail, although many possible causative factors have been suggested, including gender, diabetes mellitus, trauma, hormonal imbalance, and dietary habits.Methods: A self-administered questionnaire was obtained from 69 patients with ossification of the posterior longitudinal ligament of the spine and 138 sex- and age-matched control participants who were free of spinal disease, randomly selected from participants in a health checkup in a town. After univariate analysis, a stepwise method was applied to select significant factors in multivariate analysis.Results. A multivariate analysis revealed that the following three indicators were independent potent risk factors for ossification of the posterior longitudinal ligament of the spine: history of diabetes mellitus, history of lumbago, and maximum body mass index before manifestation greater than or equal to25, after adjustment for other possible lifestyle risk factors.Conclusion. Excessive weight gain between 20 and 40 years of age, diabetes mellitus, and lumbago were found to be independent risk factors for ossification of the posterior longitudinal ligament of the spine. Follow-up studies, including the addition of hospital-based control participants and analysis of genetic polymorphisms, will be needed in the future.