Chronic intermittent in utero exposure to morphine: effects on respiratory control in the neonatal guinea pig.
Chronic intermittent in utero exposure to morphine: effects on respiratory control in the neonatal guinea pig.
复制标题
子宫内慢性间歇性接触吗啡：对新生豚鼠呼吸控制的影响。
DOI：
10.1159/000244496
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Olsen,GD
中科院分区：
文献类型：
--
作者：
Hunter,MA;Vangelisti,GR;Olsen,GD
本研究旨在确定妊娠后半期在子宫内慢性间歇性接触吗啡 (MOR) 是否会导致新生儿通气不足和对 CO2 的通气敏感性降低。怀孕的豚鼠被随机分配每天一次接受盐水和 1.5、5.0 或 15.0mg/kg MOR 的治疗。对新生儿进行了为期三周的研究。产前暴露于 5.0 和 15.0 mg/kg MOR 显着增加新生儿每分钟通气量和第 7 天呼吸室内空气或 5% CO2 时的中枢吸气动力。每分钟通气量的增加是戒断综合征的一部分，包括运动活动增加，但并不是由于代谢率或对二氧化碳敏感性的增加。我们得出的结论是，在妊娠后半段每天接触 MOR 一次的新生豚鼠在出生后第一周内会出现过度换气。这些变化既不是永久性的，也不会导致通气不足或对二氧化碳的敏感性降低。
This study was done to determine if chronic intermittent in utero exposure to morphine (MOR) during the last half of gestation results in hypoventilation and decreased ventilatory sensitivity to CO2in the neonate. Pregnant guinea pigs were randomly assigned to once-daily treatment with saline and 1.5, 5.0, or 15.0mg/kg MOR. Neonates were studied for 3 weeks. Prenatal exposure to 5.0 and 15.0 mg/kg MOR significantly increased neonatal minute ventilation and central inspiratory drive on day 7 while breathing room air or 5% CO2. The increase in minute ventilation was part of a withdrawal syndrome that included increased locomotor activity, but was not due to an increase in metabolic rate or sensitivity to CO2. We conclude that neonatal guinea pigs exposed once daily to MOR during the last half of gestation hyperventilate during the 1 st week after birth. These changes are neither permanent nor followed by hypoventilation or depressed sensitivity to CO2.